Patent Information

    • DRAMP ID

    • DRAMP36356

    • Sequence

    • WTYIF

    • Sequence Length

    • 5

    • Sequence Name

    • coloy(Trp-Thr-Tyr-Ile-Phe)

    • Source

    • Frog fecal mildew

    • Activity

    • Antimicrobial, Anticancer

    • Patent Type

    • Patent Application

    • Publication Date

    • 2023-1-24

    • Patent Title

    • Cyclic cyclo chrosurotyroisoleucine with hepatoma carcinoma cytotoxicity and alpha-glucosidase inhibitory activity and preparation method of

    • Abstract

    • The invention relates to a cyclo-threo casein iso-brilliant phenylpropanoid peptide (cyclo-Trp-Thr-Tyr-Ile-Phe cyclic peptide) with hepatotoxicity and alpha-glucosidase inhibition activity and a preparation method thereof, belonging to the technical field of extraction and preparation of biological products. The cyclic cyclo-chromo-threo-casein-isoleucin-phenylpropanoid is prepared from cyclo-tryptophan, threonine, tyrosine, isoleucine and phenylalanine, and is a pentadecatomic cyclic pentapeptide formed by connecting amide bonds. This is a novel compound and has not been reported in the literature. The compound of the invention can be obtained by culturing ranunculus japonicus and then extracting and separating. The pure product of the cyclocyclo-chromo-threo-casein-isoleucin is white powder and has half Inhibition Concentration (IC) on hepatoma carcinoma cell HepG2 50 ) Comprises the following steps: 111.07. Mu.g/mL, half inhibitory concentration of alpha-glucosidase (IC) 50 ) Comprises the foll