General Information

    • DRAMP ID

    • DRAMP29852

    • Peptide Name

    • Com7

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • CRRWWRFC

    • Sequence Length

    • 8

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli(LD99=30 µM);
      • Gram-positive bacteria: Staphylococcus aureus(LD99=1.9 µM), Bacillus subtilis(LD99≦0.45 µM).

    • Hemolytic Activity

      • None of the peptides are hemolytic

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Human Serum

    • Stability Data

    • Resistant with ∼50% intact peptide left after an incubation time of 6.5 h.

    • Assay

    • RP-HPLC

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Acetylation and Cyclization(Cys1 and Cys8)

    • C-terminal Modification

    • Amidation and Cyclization(Cys1 and Cys8)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys1 and Cys8.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29852.

Literature Information

  • ·Literature 1

    • Title

    • Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs.

    • Reference

    • PLoS One. 2010 Sep 10;5(9):e12684.

    • Author

    • Nguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ.