• DRAMP ID

    • DRAMP29922
    • Peptide Name

    • GnRH-III(4Lys(Ac),8Lys(DaudAoa))
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • HWKHDWKPG
    • Sequence Length

    • 9
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Anti-cancer
    • Target Organism

    • No LC50s found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • [Ref.21668011]IC50=2.6±0.8 μM against MCF-7 human breast cell lines, IC50=8.1±2.6 μM against HT-29 human colon cell lines, IC50=5.1±0.4 μM against LNCaP human prostate cancer cell lines .
    • Binding Target

    • Not found
    • Serum or Protease Type

    • Trypsin, ?-chymotrypsin, and pepsin
    • Stability Data

    • All bioconjugates showed high stability in the presence of pepsin even after 27 h of incubation, as no proteolytic fragmentswere identified by LC-MS
    • Assay

    • LC-MS
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • K(8)=(Dau=Aoa)
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP29922.
  • ·Literature 1
    • Title

    • Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4.
    • Reference

    • Bioconjug Chem. 2011 Jul 20;22(7):1320-9.
    • Author

    • Manea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G.