General Information

    • DRAMP ID

    • DRAMP29925

    • Peptide Name

    • HPA3NT3-A2D

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AkRLkkLAkkIWkWk

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli(MIC=4 µM), Escherichia coli CCARM 1229(MIC=1 µM), Escherichia coli CCARM 1238(MIC=2 µM), Pseudomonas aeruginosa 3547(MIC=2 µM), Pseudomonas aeruginosa 4007(MIC=4 µM), Salmonella typhimurium CCARM 8009(MIC=8 µM), Salmonella typhimurium CCARM 8013(MIC=4 µM);
      • Gram-positive bacteria: Staphylococcus aureus(MIC=2 µM), Staphylococcus aureus CCARM 3089(MIC=4 µM), Staphylococcus aureus CCARM 3114(MIC=2 µM), Staphylococcus aureus PBEL 1(MIC=4 µM), Staphylococcus aureus PBEL 2(MIC=4 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Not mentioned

    • Stability Data

    • Remaining 100% more than 120min

    • Assay

    • Radial diffusion assays

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • D-Lys at 2nd, 5th, 6th, 9th, 10th, 13th, and 15th position

    • Stereochemistry

    • Mixed

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29925.

Literature Information

  • ·Literature 1

    • Title

    • All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance

    • Reference

    • Int J Mol Sci. 2020 Aug 6;21(16):5632.

    • Author

    • Lee JK, Park Y