General Information

    • DRAMP ID

    • DRAMP29946

    • Peptide Name

    • Aurein-1.2 [E11A]

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFDIIKKIAASF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli ATCC 25922(MIC=16 µg/ml), Pseudomonas aeruginosa ATCC 9027(MIC=64 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923(MIC=32 µg/ml), Enterococcus faecalis(MIC=32 µg/ml);
      • Fungi: Candida albicans ATCC 10231(MIC=32µg/ml).

    • Hemolytic Activity

      • All the analogs were less hemolytically active against human RBCs

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Fetal bovine serum

    • Stability Data

    • 37℃，in fetal bovine serum, 17% remaining after 6h

    • Assay

    • LC-MS

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29946.

Literature Information

  • ·Literature 1

    • Title

    • Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2.

    • Reference

    • Probiotics Antimicrob Proteins. 2019 Sep;11(3):1042-1054.

    • Author

    • Migoń D, Jaśkiewicz M, Neubauer D, Bauer M, Sikorska E, Kamysz E, Kamysz W.