General Information

    • DRAMP ID

    • DRAMP00001

    • Peptide Name

    • Variacin (Bacteriocin)

    • Source

    • Micrococcus varians (Gram-positive bacteria)

    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • GSGVIPTISHECHMNSFQFVFTCCS

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Lactobacillus helveticus (+++), L. bulgaricus (+++), Lactobacillus lactis (++), Lactobacillus delbrueckii (+++), Lactobacillus acidophilus (++), Lactobacillus plantarum (+), Lactobacillus sake (LSK) (++), Lactobacillus curvatus (++), Leuconostoc mesenteroides (+), Streptococcus thermophilus (++), Lactococcus lactis (SL2) (++), Enterococcus faecalis (++), Enterococcus faecium (++), Listeria innocua (++), Listeria monocytogenes (++++), Listeria welhia (++).
      • Note: Inhibitory activity tested with supernatant adjusted to pH 7.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not found

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00001 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C118H175N31O36S4

    • Absent Amino Acids

    • ADKLRWY

    • Common Amino Acids

    • S

    • Mass

    • 2732.11

    • PI

    • 5.98

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • -12.12

    • Hydrophobicity

    • 0.452

    • Aliphatic Index

    • 54.4

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.21

    • Polar Residues

    • 12

DRAMP00001

DRAMP00001 chydropathy plot

Comments Information

    • Function

    • Has a broad host range of inhibition against Gram-positive food spoilage bacteria. Variacin is resistant to heat and pH conditions from 2 to 10.

    • Biophysicochemical properties

    • Variacin is resistant to heat and pH conditions from 2 to 10.

Literature Information

  • ·Literature 1

    • Title

    • Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis.

    • Reference

    • Appl Environ Microbiol. 1996 May;62(5):1799-1802.

    • Author

    • Pridmore D, Rekhif N, Pittet AC, Suri B, Mollet B.