General Information

    • DRAMP ID

    • DRAMP00003

    • Peptide Name

    • Bovicin HJ50 (Bacteriocin; Predicted)

    • Source

    • Streptococcus bovis HJ50 (Gram-positive bacteria)

    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)

    • Gene

    • bovA

    • Sequence

    • ADRGWIKTLTKDCPNVISSICAGTIITACKNCA

    • Sequence Length

    • 33

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus megaterium AS1.941 (IZ=14 mm), Bacillus subtilis AS1.1087 (IZ=12 mm), Lactobacillus curvatus LTH1174 (IZ=13 mm), Leuconostoc mesenteroides AS1.2 (IZ=10 mm), Leuconostoc dextranicum 181 (IZ=13 mm), Micrococcus flavus NCIB8166 (IZ=21 mm).
      • NOTE: IZ = zone of inhibition.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00003 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP00003.

Physicochemical Information

    • Formula

    • C147H248N42O46S4

    • Absent Amino Acids

    • EFHMQY

    • Common Amino Acids

    • I

    • Mass

    • 3468.08

    • PI

    • 8.53

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • -29.24

    • Hydrophobicity

    • 0.297

    • Aliphatic Index

    • 91.82

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5750

    • Absorbance 280nm

    • 179.69

    • Polar Residues

    • 14

DRAMP00003

DRAMP00003 chydropathy plot

Comments Information

    • PTM

    • There are two thioether rings (T8-C13 and T10-C32) and one unique disulfide bridge between C21-C29.

Literature Information

  • ·Literature 1

    • Title

    • Bovicin HJ50, a novel lantibiotic produced by Streptococcus bovis HJ50.

    • Reference

    • Microbiology. 2004 Jan;150(Pt 1):103-108.

    • Author

    • Xiao H, Chen X, Chen M, Tang S, Zhao X, Huan L.
  • ·Literature 2

    • Title

    • Characteristics of the bovicin HJ50 gene cluster in Streptococcus bovis HJ50.

    • Reference

    • Microbiology. 2009 Feb;155(Pt 2):584-593.

    • Author

    • Liu G, Zhong J, Ni J, Chen M, Xiao H, Huan L.