• DRAMP ID

    • DRAMP00003
    • Peptide Name

    • Bovicin HJ50 (Bacteriocin; Predicted)
    • Source

    • Streptococcus bovis HJ50 (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • bovA
    • Sequence

    • ADRGWIKTLTKDCPNVISSICAGTIITACKNCA
    • Sequence Length

    • 33
    • Evidence code

    • Predicted
    • Biological Activity

    • Antibacterial
    • Target Organism

      • Gram-positive bacteria: Bacillus megaterium AS1.941 (IZ=14 mm), Bacillus subtilis AS1.1087 (IZ=12 mm), Lactobacillus curvatus LTH1174 (IZ=13 mm), Leuconostoc mesenteroides AS1.2 (IZ=10 mm), Leuconostoc dextranicum 181 (IZ=13 mm), Micrococcus flavus NCIB8166 (IZ=21 mm).
      • NOTE: IZ = zone of inhibition.
    • Hemolytic activity

    • Unknown
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP00003 helical wheel diagram
    • Formula

    • C147H248N42O46S4
    • Absent Amino Acids

    • EFHMQY
    • Common Amino Acids

    • I
    • Mass

    • 4039.08
    • PI

    • 8.34
    • Basic Residues

    • 4
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 12
    • Boman Index

    • -29.24
    • Hydrophobicity

    • 29.7
    • Aliphatic Index

    • 91.82
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5750
    • Absorbance 280nm

    • 179.69
    • Polar Residues

    • 14

DRAMP00003

DRAMP00003 chydropathy plot
    • PTM

    • There are two thioether rings (T8-C13 and T10-C32) and one unique disulfide bridge between C21-C29.
  • Literature 1
    • Reference

    • Microbiology. 2004 Jan;150(Pt 1):103-108.
    • Author

    • Xiao H, Chen X, Chen M, Tang S, Zhao X, Huan L.
    • Title

    • Bovicin HJ50, a novel lantibiotic produced by Streptococcus bovis HJ50.
  • Literature 2
    • Reference

    • Microbiology. 2009 Feb;155(Pt 2):584-593.
    • Author

    • Liu G, Zhong J, Ni J, Chen M, Xiao H, Huan L.
    • Title

    • Characteristics of the bovicin HJ50 gene cluster in Streptococcus bovis HJ50.