• DRAMP ID

    • DRAMP00011
    • Peptide Name

    • Plantaricin W beta (Plw-beta; Bacteriocin)
    • Source

    • Lactobacillus plantarum (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • plWbeta
    • Sequence

    • SGIPCTIGAAVAASIAVCPTTKCSKRCGKRKK
    • Sequence Length

    • 32
    • Evidence code

    • Predicted
    • Biological Activity

    • Antibacterial
    • Target Organism

      • Gram-positive bacteria: Lactobacillus spp, Lactococcus lactis, Listeria innocua, Listeria monocytogenes, Oenococcus oeni, Leuconostoc mesenteroides, Pediococcus acidilactici, Pediococcus pentosaceus, Enterococcus faecalis, Propionibacterium freudenreichii, Staphylococcus aureus.
    • Hemolytic activity

    • Unknown
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP00011 helical wheel diagram
    • Formula

    • C134H241N43O39S4
    • Absent Amino Acids

    • DEFHLMNQWY
    • Common Amino Acids

    • AK
    • Mass

    • 3760.03
    • PI

    • 10.63
    • Basic Residues

    • 7
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Boman Index

    • -35.67
    • Hydrophobicity

    • 10.94
    • Aliphatic Index

    • 70.31
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 250
    • Absorbance 280nm

    • 8.06
    • Polar Residues

    • 13

Amino Acid Distribution

DRAMP00011 chydropathy plot
    • Function

    • Plantaricin W (Plw) is a new two-peptide bacteriocin, from Lactobacillus plantarum, which inhibits a large number of Gram-positive bacteria. The two individual peptides, Plwalpha (comprising 29 residues) and Plwbeta (comprising 32 residues), had low antimicrobial activity but acted synergistically. The data indicate that the two peptides work in a 1
    • PTM

    • Chemical analyses showed that both peptides are lantibiotics, but two unmodified cysteines and one serine residue were present in Plwa, and Plwb contained one cysteine residue. Plwbeta is synthesized with a 29 aa leader, processed by an ABC transporter and then subjected to further proteolytic attack, resulting in the removal of the six Nterminal residues.
  • Literature 1
    • Reference

    • Microbiology. 2001 Mar;147(Pt 3):643-651.
    • Author

    • Holo H, Jeknic Z, Daeschel M, Stevanovic S, Nes IF.
    • Title

    • Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics.