• DRAMP ID

    • DRAMP00015
    • Peptide Name

    • Geobacillin II (nisin analog; Bacteriocin)
    • Source

    • Geobacillus thermodenitrificans NG80-2 (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • STIVCVSLRICNWSLRFCPSFKVRCPM
    • Sequence Length

    • 27
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacteria: Bacillus cereus Z4222, Bacillus subtilis ATCC 6633.
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization between S29 and C33
    • Other Modifications and Unusual Amino Acids

    • Four lanthionines (S3-C7,S23-C27,S26-C30,S29-C33) and three β-methyllanthionines (T8-C11; T13-C18; T20-C24),S5 is dehydroalanines.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • DRAMP00015 helical wheel diagram
    • Formula

    • C139H225N39O34S5
    • Absent Amino Acids

    • ADEGHQY
    • Common Amino Acids

    • CS
    • Mass

    • 3610.78
    • PI

    • 9.11
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Boman Index

    • -25.56
    • Hydrophobicity

    • 0.659
    • Aliphatic Index

    • 90
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5750
    • Absorbance 280nm

    • 221.15
    • Polar Residues

    • 10

DRAMP00015

DRAMP00015 chydropathy plot
    • Function

    • Geobacillin II only demonstrated antimicrobial activity against Bacillus strains.
  • ·Literature 1
    • Title

    • Lantibiotics from Geobacillus thermodenitrificans.
    • Reference

    • Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5241-5246.
    • Author

    • Garg N, Tang W, Goto Y, Nair SK, van der Donk WA.