• DRAMP ID

    • DRAMP00015
    • Peptide Name

    • Geobacillin II (nisin analog; Bacteriocin)
    • Source

    • Geobacillus thermodenitrificans NG80-2 (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • Unknow
    • Sequence

    • STIVCVSLRICNWSLRFCPSFKVRCPM
    • Sequence Length

    • 27
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial
    • Target Organism

      • Gram-positive bacteria: Bacillus cereus Z4222, Bacillus subtilis ATCC 6633.
    • Hemolytic activity

    • Unknown
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP00015 helical wheel diagram
    • Formula

    • C139H225N39O34S5
    • Absent Amino Acids

    • ADEGHQY
    • Common Amino Acids

    • CS
    • Mass

    • 3610.78
    • PI

    • 9.11
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Boman Index

    • -25.56
    • Hydrophobicity

    • 65.93
    • Aliphatic Index

    • 90
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5750
    • Absorbance 280nm

    • 221.15
    • Polar Residues

    • 10

Amino Acid Distribution

DRAMP00015 chydropathy plot
    • Function

    • Geobacillin II only demonstrated antimicrobial activity against Bacillus strains.
  • Literature 1
    • Reference

    • Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5241-5246.
    • Author

    • Garg N, Tang W, Goto Y, Nair SK, van der Donk WA.
    • Title

    • Lantibiotics from Geobacillus thermodenitrificans.