• • DRAMP ID

  • DRAMP00015

• • Peptide Name

  • Geobacillin II (nisin analog; Bacteriocin)

• • Source

  • Geobacillus thermodenitrificans NG80-2 (Gram-positive bacteria)

• • Family

  • Belongs to the lantibiotic family (Class I bacteriocin)

• • Gene

  • Not found

• • Sequence

  • STIVCVSLRICNWSLRFCPSFKVRCPM

• • Sequence Length

  • 27

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+

• • Target Organism

  • • Gram-positive bacteria: Bacillus cereus Z4222, Bacillus subtilis ATCC 6633.

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization between S29 and C33

• • Nonterminal Modifications and Unusual Amino Acids

  • Four lanthionines (S3-C7,S23-C27,S26-C30,S29-C33) and three β-methyllanthionines (T8-C11; T13-C18; T20-C24),S5 is dehydroalanines.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP00015.

DRAMP00015

• • Function

  • Geobacillin II only demonstrated antimicrobial activity against Bacillus strains.

• ·Literature 1

• • Title

  • Lantibiotics from Geobacillus thermodenitrificans.

• • Pubmed ID

  • 22431611

• • Reference

  • Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5241-5246.

• • Author

  • Garg N, Tang W, Goto Y, Nair SK, van der Donk WA.