• DRAMP ID

    • DRAMP00023
    • Peptide Name

    • Staphylococcin C55beta (SacAbeta; chain beta of Staphylococcin C55; Bacteriocin)
    • Source

    • Staphylococcus aureus C55 (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • GTPLALLGGAATGVIGYISNQTCPTTACTRAC
    • Sequence Length

    • 32
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Not found
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus, Micrococcus luteus (C55alpha and C55beta work synergistically at a ratio of 1:1).
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • DRAMP00023 helical wheel diagram
    • Formula

    • C130H217N37O43S3
    • Absent Amino Acids

    • DEFHKMW
    • Common Amino Acids

    • T
    • Mass

    • 3635.71
    • PI

    • 8.04
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 11
    • Boman Index

    • 0.17
    • Hydrophobicity

    • 0.566
    • Aliphatic Index

    • 85.63
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1615
    • Absorbance 280nm

    • 52.1
    • Polar Residues

    • 17

DRAMP00023

DRAMP00023 chydropathy plot
    • Function

    • Active on certain Gram-positive bacteria.
  • ·Literature 1
    • Title

    • Two-component anti-Staphylococcus aureus lantibiotic activity produced by Staphylococcus aureus C55.
    • Reference

    • Appl Environ Microbiol. 1998 Dec;64(12):4803-4808.
    • Author

    • Navaratna MA, Sahl HG, Tagg JR.
  • ·Literature 2
    • Title

    • Identification of genes encoding two-component lantibiotic production in Staphylococcus aureus C55 and other phage group II Staphylococcus aureus strains and demonstration of an association with the exfoliative toxin B gene.
    • Reference

    • Infect Immun. 1999 Aug;67(8):4268-4271.
    • Author

    • Navaratna MA, Sahl HG, Tagg JR.