• DRAMP ID

    • DRAMP00026
    • Peptide Name

    • Salivaricin A (SalA; Bacteriocin; Preclinical)
    • Source

    • Streptococcus salivarius 20P3 (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • salA
    • Sequence

    • KRGSGWIATITDDCPNSVFVCC
    • Sequence Length

    • 22
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Rich
    • Structure Description

    • Not found
    • DRAMP00026 helical wheel diagram
    • Formula

    • C101H158N28O32S3
    • Absent Amino Acids

    • EHLMQY
    • Common Amino Acids

    • C
    • Mass

    • 2747.48
    • PI

    • 6.11
    • Basic Residues

    • 2
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 7
    • Boman Index

    • -25.73
    • Hydrophobicity

    • 0.196
    • Aliphatic Index

    • 66.36
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 267.86
    • Polar Residues

    • 10

DRAMP00026

DRAMP00026 chydropathy plot
    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
    • PTM

    • Contains one lanthionine (S17-C22) and two Beta-methyllanthionines (T9-C14; T11-C21), which is followed by membrane translocation and cleavage of the modified precursor.
  • ·Literature 1
    • Title

    • Isolation and characterization of the lantibiotic salivaricin A and its structural gene salA from Streptococcus salivarius 20P3.
    • Reference

    • Appl Environ Microbiol. 1993 Jul;59(7):2014-2021.
    • Author

    • Ross KF, Ronson CW, Tagg JR.