General Information

    • DRAMP ID

    • DRAMP00026

    • Peptide Name

    • Salivaricin A (SalA; Bacteriocin; Preclinical)

    • Source

    • Streptococcus salivarius 20P3 (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • salA

    • Sequence

    • KRGSGWIATITDDCPNSVFVCC

    • Sequence Length

    • 22

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00026 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00026.

Physicochemical Information

    • Formula

    • C101H158N28O32S3

    • Absent Amino Acids

    • EHLMQY

    • Common Amino Acids

    • C

    • Mass

    • 2372.71

    • PI

    • 5.94

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 7

    • Net Charge

    • 0

    • Boman Index

    • -25.73

    • Hydrophobicity

    • 0.196

    • Aliphatic Index

    • 66.36

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 267.86

    • Polar Residues

    • 10

DRAMP00026

DRAMP00026 chydropathy plot

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

    • PTM

    • Contains one lanthionine (S17-C22) and two Beta-methyllanthionines (T9-C14; T11-C21), which is followed by membrane translocation and cleavage of the modified precursor.

Literature Information

  • ·Literature 1

    • Title

    • Isolation and characterization of the lantibiotic salivaricin A and its structural gene salA from Streptococcus salivarius 20P3.

    • Reference

    • Appl Environ Microbiol. 1993 Jul;59(7):2014-2021.

    • Author

    • Ross KF, Ronson CW, Tagg JR.