• DRAMP ID

    • DRAMP00027
    • Peptide Name

    • Salivaricin B (SboB; Bacteriocin; Preclinical)
    • Source

    • Streptococcus salivarius K12 (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • GGGVIQTISHECRMNSWQFLFTCCS
    • Sequence Length

    • 25
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Not found
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • DRAMP00027 helical wheel diagram
    • Formula

    • C120H182N34O36S4
    • Absent Amino Acids

    • ADKPY
    • Common Amino Acids

    • CGS
    • Mass

    • 3233.48
    • PI

    • 7.18
    • Basic Residues

    • 2
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 7
    • Boman Index

    • -23.35
    • Hydrophobicity

    • 0.176
    • Aliphatic Index

    • 58.4
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 234.38
    • Polar Residues

    • 12

DRAMP00027

DRAMP00027 chydropathy plot
    • PTM

    • Thioether bonds are predicted between 7-12; 9-23; 16-24.
  • ·Literature 1
    • Title

    • Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain Streptococcus salivarius K12.
    • Reference

    • Appl Environ Microbiol. 2007 Feb;73(4):1107-1113.
    • Author

    • Hyink O, Wescombe PA, Upton M, Ragland N, Burton JP, Tagg JR.