General Information

    • DRAMP ID

    • DRAMP00027

    • Peptide Name

    • Salivaricin B (SboB; Bacteriocin; Preclinical)

    • Source

    • Streptococcus salivarius K12 (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • GGGVIQTISHECRMNSWQFLFTCCS

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00027 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00027.

Physicochemical Information

    • Formula

    • C120H182N34O36S4

    • Absent Amino Acids

    • ADKPY

    • Common Amino Acids

    • CGS

    • Mass

    • 2805.21

    • PI

    • 6.72

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • -23.35

    • Hydrophobicity

    • 0.176

    • Aliphatic Index

    • 58.4

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 234.38

    • Polar Residues

    • 12

DRAMP00027

DRAMP00027 chydropathy plot

Comments Information

    • PTM

    • Thioether bonds are predicted between 7-12; 9-23; 16-24.

Literature Information

  • ·Literature 1

    • Title

    • Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain Streptococcus salivarius K12.

    • Reference

    • Appl Environ Microbiol. 2007 Feb;73(4):1107-1113.

    • Author

    • Hyink O, Wescombe PA, Upton M, Ragland N, Burton JP, Tagg JR.