• DRAMP ID

    • DRAMP00029
    • Peptide Name

    • Streptococcin A-FF22 (Antibacterial peptide SA-FF22; Bacteriocin)
    • Source

    • Streptococcus pyogenes FF22 (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • scnA
    • Sequence

    • GKNGVFKTISHECHLNTWAFLATCCS
    • Sequence Length

    • 26
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Cell membrane
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • DRAMP00029 helical wheel diagram
    • Formula

    • C126H191N35O36S3
    • Absent Amino Acids

    • DMPQRY
    • Common Amino Acids

    • CT
    • Mass

    • 3314.41
    • PI

    • 8.07
    • Basic Residues

    • 4
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 9
    • Boman Index

    • -18.59
    • Hydrophobicity

    • 0.112
    • Aliphatic Index

    • 63.85
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 225
    • Polar Residues

    • 12

DRAMP00029

DRAMP00029 chydropathy plot
    • Function Lanthionine-containing peptide antibiotic (lantibiotic) active on certain Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

    • PTM

    • There are one 2,3-didehydrobutyrine at T23, two Beta-methyllanthionine (T8-C13; T17-C25), and one Lanthionine (S10-C24).
  • ·Literature 1
    • Title

    • Cloning of the gene encoding Streptococcin A-FF22, a novel lantibiotic produced by Streptococcus pyogenes, and determination of its nucleotide sequence.
    • Reference

    • Appl Environ Microbiol. 1993 Jun;59(6):1969-1971.
    • Author

    • Hynes WL, Ferretti JJ, Tagg JR.
  • ·Literature 2
    • Title

    • Elucidation of the structure of SA-FF22, a lanthionine-containing antibacterial peptide produced by Streptococcus pyogenes strain FF22.
    • Reference

    • Eur J Biochem. 1994 Mar 1;220(2):455-462.
    • Author

    • Jack RW, Carne A, Metzger J, Stefanović S, Sahl HG, Jung G, Tagg J.