General Information

    • DRAMP ID

    • DRAMP00029

    • Peptide Name

    • Streptococcin A-FF22 (Antibacterial peptide SA-FF22; Bacteriocin)

    • Source

    • Streptococcus pyogenes FF22 (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • scnA

    • Sequence

    • GKNGVFKTISHECHLNTWAFLATCCS

    • Sequence Length

    • 26

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00029 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00029.

Physicochemical Information

    • Formula

    • C126H191N35O36S3

    • Absent Amino Acids

    • DMPQRY

    • Common Amino Acids

    • CT

    • Mass

    • 2868.3

    • PI

    • 7.97

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • -18.59

    • Hydrophobicity

    • 0.112

    • Aliphatic Index

    • 63.85

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 225

    • Polar Residues

    • 12

DRAMP00029

DRAMP00029 chydropathy plot

Comments Information

    • Function Lanthionine-containing peptide antibiotic (lantibiotic) active on certain Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

    • PTM

    • There are one 2,3-didehydrobutyrine at T23, two Beta-methyllanthionine (T8-C13; T17-C25), and one Lanthionine (S10-C24).

Literature Information

  • ·Literature 1

    • Title

    • Cloning of the gene encoding Streptococcin A-FF22, a novel lantibiotic produced by Streptococcus pyogenes, and determination of its nucleotide sequence.

    • Reference

    • Appl Environ Microbiol. 1993 Jun;59(6):1969-1971.

    • Author

    • Hynes WL, Ferretti JJ, Tagg JR.
  • ·Literature 2

    • Title

    • Elucidation of the structure of SA-FF22, a lanthionine-containing antibacterial peptide produced by Streptococcus pyogenes strain FF22.

    • Reference

    • Eur J Biochem. 1994 Mar 1;220(2):455-462.

    • Author

    • Jack RW, Carne A, Metzger J, Stefanović S, Sahl HG, Jung G, Tagg J.