• DRAMP ID

    • DRAMP00031
    • Peptide Name

    • Lantibiotic carnocin-UI49 (Bacteriocin)
    • Source

    • Carnobacterium sp. (strain UI49) (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • GSEIQPR
    • Sequence Length

    • 7
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus sakei, L. lactis, Pediococcus acidilactici, all Carnobacterium species (six NCDO strains).
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Rich
    • Structure Description

    • Not found
    • DRAMP00031 helical wheel diagram
    • Formula

    • C32H55N11O12
    • Absent Amino Acids

    • ACDFHKLMNTVWY
    • Common Amino Acids

    • EGIPQRS
    • Mass

    • 893.05
    • PI

    • 6.41
    • Basic Residues

    • 1
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 1
    • Boman Index

    • -24.81
    • Hydrophobicity

    • -1.4
    • Aliphatic Index

    • 55.71
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP00031

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic). Active on Gram-positive bacteria.
    • Biophysicochemical properties

    • Bacteriocin activity is very stable below pH 8 and is moderately heat stable in the crude extract.
  • ·Literature 1
    • Title

    • Purification and characterization of a new bacteriocin isolated from a Carnobacterium sp.
    • Reference

    • Appl Environ Microbiol. 1992;58(5):1417-1422.
    • Author

    • Stoffels G, Nissen-Meyer J, Gudmundsdottir A, Sletten K, Holo H, Nes IF.