General Information

    • DRAMP ID

    • DRAMP00031

    • Peptide Name

    • Lantibiotic carnocin-UI49 (Bacteriocin)

    • Source

    • Carnobacterium sp. (strain UI49) (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • GSEIQPR

    • Sequence Length

    • 7

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus sakei, L. lactis, Pediococcus acidilactici, all Carnobacterium species (six NCDO strains).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00031 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00031.

Physicochemical Information

    • Formula

    • C32H55N11O12

    • Absent Amino Acids

    • ACDFHKLMNTVWY

    • Common Amino Acids

    • EGIPQRS

    • Mass

    • 785.86

    • PI

    • 6

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 1

    • Net Charge

    • 0

    • Boman Index

    • -24.81

    • Hydrophobicity

    • -1.4

    • Aliphatic Index

    • 55.71

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP00031

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic). Active on Gram-positive bacteria.

    • Biophysicochemical properties

    • Bacteriocin activity is very stable below pH 8 and is moderately heat stable in the crude extract.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of a new bacteriocin isolated from a Carnobacterium sp.

    • Reference

    • Appl Environ Microbiol. 1992;58(5):1417-1422.

    • Author

    • Stoffels G, Nissen-Meyer J, Gudmundsdottir A, Sletten K, Holo H, Nes IF.