• DRAMP ID

    • DRAMP00033
    • Peptide Name

    • Lantibiotic epilancin 15X (Bacteriocin)
    • Source

    • Staphylococcus epidermidis 15X154 (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • ASIVKTTIKASKKLCRGFTLTCGCHFTGKK
    • Sequence Length

    • 30
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: resistant bacterial strains Staphylococcus aureus (MRSA) and VRE.
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Non helix or strand structure
    • Structure Description

    • The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety.
    • PDB ID

    • 1W9N resolved by NMR.
    • DRAMP00033 helical wheel diagram
    • 1W9N-> 
    • Formula

    • C142H243N41O38S3
    • Absent Amino Acids

    • DEMNPQWY
    • Common Amino Acids

    • K
    • Mass

    • 3746.38
    • PI

    • 10.8
    • Basic Residues

    • 8
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Boman Index

    • -32.57
    • Hydrophobicity

    • 0.003
    • Aliphatic Index

    • 68.33
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 4.31
    • Polar Residues

    • 13

DRAMP00033

DRAMP00033 chydropathy plot
    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria
    • PTM

    • There are one Lactic acid (S1), one 2,3-didehydroalanine (S3) and three 2,3-dehydrobutyrines (T7; T8; T28); also one Lanthionine (S12-C16) and two Beta-methyllanthionines (T20-C23; T22-C25).
  • ·Literature 1
    • Title

    • Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis.
    • Reference

    • FEBS Lett. 2005 Mar 28;579(9):1917-1922.
    • Author

    • Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA.