General Information

    • DRAMP ID

    • DRAMP00034

    • Peptide Name

    • Lantibiotic epilancin K7 (Bacteriocin)

    • Source

    • Staphylococcus epidermidis K7 (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • elkA

    • Sequence

    • SASVLKTSIKVSKKYCKGVTLTCGCNITGGK

    • Sequence Length

    • 31

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00034 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00034.

Physicochemical Information

    • Formula

    • C136H240N38O42S3

    • Absent Amino Acids

    • DEFHMPQRW

    • Common Amino Acids

    • K

    • Mass

    • 3175.81

    • PI

    • 9.74

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +6

    • Boman Index

    • -22.75

    • Hydrophobicity

    • 0.087

    • Aliphatic Index

    • 81.61

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 53.83

    • Polar Residues

    • 17

DRAMP00034

DRAMP00034 chydropathy plot

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

    • PTM

    • There are two dihydroalanines (Dha)

Literature Information

  • ·Literature 1

    • Title

    • Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermidis K7. Cloning and characterisation of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7.

    • Reference

    • Eur J Biochem. 1995 Jun 1;230(2):587-600.

    • Author

    • van de Kamp M, van den Hooven HW, Konings RN, Bierbaum G, Sahl HG, Kuipers OP, Siezen RJ, de Vos WM, Hilbers CW, van de Ven FJ.