• DRAMP ID

    • DRAMP00034
    • Peptide Name

    • Lantibiotic epilancin K7 (Bacteriocin)
    • Source

    • Staphylococcus epidermidis K7 (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • elkA
    • Sequence

    • SASVLKTSIKVSKKYCKGVTLTCGCNITGGK
    • Sequence Length

    • 31
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Cell membrane
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Rich
    • Structure Description

    • Not found
    • DRAMP00034 helical wheel diagram
    • Formula

    • C136H240N38O42S3
    • Absent Amino Acids

    • DEFHMPQRW
    • Common Amino Acids

    • K
    • Mass

    • 3711.1
    • PI

    • 10.3
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Boman Index

    • -22.75
    • Hydrophobicity

    • 0.087
    • Aliphatic Index

    • 81.61
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1615
    • Absorbance 280nm

    • 53.83
    • Polar Residues

    • 17

DRAMP00034

DRAMP00034 chydropathy plot
    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
    • PTM

    • There are two dihydroalanines (Dha)
  • ·Literature 1
    • Title

    • Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermidis K7. Cloning and characterisation of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7.
    • Reference

    • Eur J Biochem. 1995 Jun 1;230(2):587-600.
    • Author

    • van de Kamp M, van den Hooven HW, Konings RN, Bierbaum G, Sahl HG, Kuipers OP, Siezen RJ, de Vos WM, Hilbers CW, van de Ven FJ.