General Information

    • DRAMP ID

    • DRAMP00040

    • Peptide Name

    • Gallidermin (Bacteriocin; Preclinical)

    • Source

    • Staphylococcus gallinarum TU 3928 (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • gdmA

    • Sequence

    • IASKFLCTPGCAKTGSFNSYCC

    • Sequence Length

    • 22

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00040 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00040.

Physicochemical Information

    • Formula

    • C99H153N25O30S4

    • Absent Amino Acids

    • DEHMQRVW

    • Common Amino Acids

    • C

    • Mass

    • 2301.69

    • PI

    • 8.52

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • -6.8

    • Hydrophobicity

    • 0.396

    • Aliphatic Index

    • 44.55

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1740

    • Absorbance 280nm

    • 82.86

    • Polar Residues

    • 13

DRAMP00040

DRAMP00040 chydropathy plot

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

    • PTM

    • There are one didehydrobutyrine (Dhb)

Literature Information

  • ·Literature 1

    • Title

    • Gallidermin: a new lanthionine-containing polypeptide antibiotic.

    • Reference

    • Eur J Biochem. 1988 Oct 15;177(1):53-59.

    • Author

    • Kellner R, Jung G, Hörner T, Zähner H, Schnell N, Entian KD, Götz F.