• DRAMP ID

    • DRAMP00043
    • Peptide Name

    • Bacteriocin nukacin (Nukacin KQ-1; Nukacin KQU-131)
    • Source

    • Staphylococcus hominis KQU-131 (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • nukA
    • Sequence

    • KKKSGVIPTVSHDCHMNTFQFMFTCCS
    • Sequence Length

    • 27
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

      • No MICs found on DRAMP database
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP00043 helical wheel diagram
    • Formula

    • C133H206N36O38S5
    • Absent Amino Acids

    • AELRWY
    • Common Amino Acids

    • CFKST
    • Mass

    • 3541.55
    • PI

    • 8.53
    • Basic Residues

    • 5
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 6
    • Boman Index

    • -33.36
    • Hydrophobicity

    • -9.26
    • Aliphatic Index

    • 35.93
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 4.81
    • Polar Residues

    • 11

DRAMP00043

DRAMP00043 chydropathy plot
    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores (By similarity).
    • Biophysicochemical properties

    • Temperature dependence (Retains 50% of its antimicrobial activity after heating at 100 degrees Celsius for 100 minutes, and retains 25% antimicrobial activity after heating at 121 Celsius for 15 minutes).
  • Literature 1
    • Reference

    • Biosci Biotechnol Biochem. 2008 Aug;72(8):2232-2235.
    • Author

    • Wilaipun P, Zendo T, Okuda K, Nakayama J, Sonomoto K.
    • Title

    • Identification of the nukacin KQU-131, a new type-A(II) lantibiotic produced by Staphylococcus hominis KQU-131 isolated from Thai fermented fish product (Pla-ra).