General Information

    • DRAMP ID

    • DRAMP00043

    • Peptide Name

    • Bacteriocin nukacin (Nukacin KQ-1; Nukacin KQU-131)

    • Source

    • Staphylococcus hominis KQU-131 (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • nukA

    • Sequence

    • KKKSGVIPTVSHDCHMNTFQFMFTCCS

    • Sequence Length

    • 27

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00043 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00043.

Physicochemical Information

    • Formula

    • C133H206N36O38S5

    • Absent Amino Acids

    • AELRWY

    • Common Amino Acids

    • CFKST

    • Mass

    • 3077.62

    • PI

    • 8.66

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -33.36

    • Hydrophobicity

    • -0.093

    • Aliphatic Index

    • 35.93

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.81

    • Polar Residues

    • 11

DRAMP00043

DRAMP00043 chydropathy plot

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores (By similarity).

    • Biophysicochemical properties

    • Temperature dependence (Retains 50% of its antimicrobial activity after heating at 100 degrees Celsius for 100 minutes, and retains 25% antimicrobial activity after heating at 121 Celsius for 15 minutes).

Literature Information

  • ·Literature 1

    • Title

    • Identification of the nukacin KQU-131, a new type-A(II) lantibiotic produced by Staphylococcus hominis KQU-131 isolated from Thai fermented fish product (Pla-ra).

    • Reference

    • Biosci Biotechnol Biochem. 2008 Aug;72(8):2232-2235.

    • Author

    • Wilaipun P, Zendo T, Okuda K, Nakayama J, Sonomoto K.