• • DRAMP ID

  • DRAMP00046

• • Peptide Name

  • Lantibiotic streptin (Bacteriocin)

• • Source

  • Streptococcus pyogenes & Streptococcus pyogenes serotype M1 (Gram-positive bacteria)

• • Family

  • Belongs to the type A lantibiotic family (Class I bacteriocin)

• • Gene

  • srtA

• • Sequence

  • GSRYLCTPGSCWKLVCFTTTVK

• • Sequence Length

  • 22

• • UniProt Entry

  • P0C0H8,Q9FDV1,P0C0H9,Q48YZ4,Q9FDV1

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+

• • Target Organism

  • Active on certain Gram-positive bacteria.

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Cell membrane

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP00046.

DRAMP00046

• • Function

  • Lanthionine-containing peptide antibiotic (lantibiotic) active on certain Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

• • Induction

  • Induces its own expression in at least strain M25.

• • Miscellaneous

  • A longer form (streptin 2, with three more amino acids at the N-terminus) is probably due to incomplete processing. Other forms also exist, some of which are due to differing levels of dehydration.

• • PTM

  • Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.

• ·Literature 1

• • Title

  • New gene cluster for lantibiotic streptin possibly involved in streptolysin S formation.

• • Pubmed ID

  • 11328600

• • Reference

  • J Biochem. 2001 May;129(5):769-775.

• • Author

  • Karaya K, Shimizu T, Taketo A.

• ·Literature 2

• • Title

  • Purification and characterization of streptin, a type A1 lantibiotic produced by Streptococcus pyogenes.

• • Pubmed ID

  • 12732544

• • Reference

  • Appl Environ Microbiol. 2003 May;69(5):2737-2747.

• • Author

  • Wescombe PA, Tagg JR.

• ·Literature 3

• • Title

  • Complete genome sequence of an M1 strain of Streptococcus pyogenes.

• • Pubmed ID

  • 11296296

• • Reference

  • Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4658-4663.

• • Author

  • Ferretti JJ, McShan WM, Ajdic D, Savic DJ, Savic G, Lyon K, Primeaux C, Sezate S, Suvorov AN, Kenton S, Lai HS, Lin SP, Qian Y, Jia HG, Najar FZ, Ren Q, Zhu H, Song L, White J, Yuan X, Clifton SW, Roe BA, McLaughlin R.

• ·Literature 4

• • Title

  • Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events.

• • Pubmed ID

  • 16088826

• • Reference

  • J Infect Dis. 2005 Sep 1;192(5):771-782.

• • Author

  • Sumby P, Porcella SF, Madrigal AG, Barbian KD, Virtaneva K, Ricklefs SM, Sturdevant DE, Graham MR, Vuopio-Varkila J, Hoe NP, Musser JM.