• DRAMP ID

    • DRAMP00046
    • Peptide Name

    • Lantibiotic streptin (Bacteriocin)
    • Source

    • Streptococcus pyogenes & Streptococcus pyogenes serotype M1 (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • srtA
    • Sequence

    • GSRYLCTPGSCWKLVCFTTTVK
    • Sequence Length

    • 22
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Active on certain Gram-positive bacteria.
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Cell membrane
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP00046 helical wheel diagram
    • Formula

    • C109H172N28O30S3
    • Absent Amino Acids

    • ADEHIMNQ
    • Common Amino Acids

    • T
    • Mass

    • 2825.66
    • PI

    • 8.95
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Boman Index

    • -14.29
    • Hydrophobicity

    • 22.73
    • Aliphatic Index

    • 61.82
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 7115
    • Absorbance 280nm

    • 338.81
    • Polar Residues

    • 12

DRAMP00046

DRAMP00046 chydropathy plot
    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on certain Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
    • Induction

    • Induces its own expression in at least strain M25.
    • Miscellaneous

    • A longer form (streptin 2, with three more amino acids at the N-terminus) is probably due to incomplete processing. Other forms also exist, some of which are due to differing levels of dehydration.
    • PTM

    • Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
  • Literature 1
    • Reference

    • J Biochem. 2001 May;129(5):769-775.
    • Author

    • Karaya K, Shimizu T, Taketo A.
    • Title

    • New gene cluster for lantibiotic streptin possibly involved in streptolysin S formation.
  • Literature 2
    • Reference

    • Appl Environ Microbiol. 2003 May;69(5):2737-2747.
    • Author

    • Wescombe PA, Tagg JR.
    • Title

    • Purification and characterization of streptin, a type A1 lantibiotic produced by Streptococcus pyogenes.
  • Literature 3
    • Reference

    • Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4658-4663.
    • Author

    • Ferretti JJ, McShan WM, Ajdic D, Savic DJ, Savic G, Lyon K, Primeaux C, Sezate S, Suvorov AN, Kenton S, Lai HS, Lin SP, Qian Y, Jia HG, Najar FZ, Ren Q, Zhu H, Song L, White J, Yuan X, Clifton SW, Roe BA, McLaughlin R.
    • Title

    • Complete genome sequence of an M1 strain of Streptococcus pyogenes.
  • Literature 4
    • Reference

    • J Infect Dis. 2005 Sep 1;192(5):771-782.
    • Author

    • Sumby P, Porcella SF, Madrigal AG, Barbian KD, Virtaneva K, Ricklefs SM, Sturdevant DE, Graham MR, Vuopio-Varkila J, Hoe NP, Musser JM.
    • Title

    • Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events.