• DRAMP ID

    • DRAMP00075
    • Peptide Name

    • Enterocin M (Bacteriocin)
    • Source

    • Enterococcus faecium AL 41 (Streptococcus faecium) (Gram-positive bacteria)
    • Family

    • Belongs to the class IIa bacteriocin
    • Gene

    • N/A
    • Sequence

    • ATRSYGNGVYCNNSKCWNVGEAKENIAGIVISGKASGL
    • Sequence Length

    • 38
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

      • No MICs found on DRAMP database
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • N/A
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • N/A
    • Structure Description

    • N/A
    • Formula

    • C168H268N50O55S2
    • Absent Amino Acids

    • DFHMPQ
    • Common Amino Acids

    • G
    • Mass

    • 4592.55
    • PI

    • 8.76
    • Basic Residues

    • 4
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 12
    • Boman Index

    • -45.27
    • Hydrophobicity

    • -22.11
    • Aliphatic Index

    • 74.47
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 8605
    • Absorbance 280nm

    • 232.57
    • Polar Residues

    • 20

DRAMP00075

DRAMP00075 chydropathy plot
    • Function

    • Bacteriocin that inhibits the growth of closely related Enterococcus species and a wide range of Gram-positive bacterial species. Inhibits the growth of several strains of the Gram-negative bacterium E.coli, but not the growth of Gram-negative Pseudomonas species.
    • Biophysicochemical properties

    • pH dependence (Stable at pH 5.0); Temperature dependence (Thermostable, retains activity after heating at 60, 80 and 100 degrees Celsius for 1 hour. Long-term storage at 4 degrees Celsius or -20 degrees Celsius does not affect activity).
  • Literature 1
    • Title

    • Isolation and characterization of a new bacteriocin, termed enterocin M, produced by environmental isolate Enterococcus faecium AL41.
    • Reference

    • J Ind Microbiol Biotechnol. 2007 Aug;34(8):533-537.
    • Author

    • Marekov¡ M, Laukov¡ A, Skaugen M, Nes I.