General Information

    • DRAMP ID

    • DRAMP00075

    • Peptide Name

    • Enterocin M (Bacteriocin)

    • Source

    • Enterococcus faecium AL 41 (Streptococcus faecium) (Gram-positive bacteria)

    • Family

    • Belongs to the class IIa bacteriocin

    • Gene

    • Not found

    • Sequence

    • ATRSYGNGVYCNNSKCWNVGEAKENIAGIVISGKASGL

    • Sequence Length

    • 38

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00075 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C168H268N50O55S2

    • Absent Amino Acids

    • DFHMPQ

    • Common Amino Acids

    • G

    • Mass

    • 3932.4

    • PI

    • 8.79

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • -45.27

    • Hydrophobicity

    • -0.221

    • Aliphatic Index

    • 74.47

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 8605

    • Absorbance 280nm

    • 232.57

    • Polar Residues

    • 20

DRAMP00075

DRAMP00075 chydropathy plot

Comments Information

    • Function

    • Bacteriocin that inhibits the growth of closely related Enterococcus species and a wide range of Gram-positive bacterial species. Inhibits the growth of several strains of the Gram-negative bacterium E.coli, but not the growth of Gram-negative Pseudomonas species.

    • Biophysicochemical properties

    • pH dependence (Stable at pH 5.0); Temperature dependence (Thermostable, retains activity after heating at 60, 80 and 100 degrees Celsius for 1 hour. Long-term storage at 4 degrees Celsius or -20 degrees Celsius does not affect activity).

Literature Information

  • ·Literature 1

    • Title

    • Isolation and characterization of a new bacteriocin, termed enterocin M, produced by environmental isolate Enterococcus faecium AL41.

    • Reference

    • J Ind Microbiol Biotechnol. 2007 Aug;34(8):533-537.

    • Author

    • Marekov¡ M, Laukov¡ A, Skaugen M, Nes I.