• DRAMP ID

    • DRAMP00076
    • Peptide Name

    • Mundticin ATO6 (Bacteriocin)
    • Source

    • Enterococcus mundtii ATO6 (Gram-positive bacteria)
    • Family

    • Belongs to the class IIa bacteriocin
    • Gene

    • Not found
    • Sequence

    • KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWSK
    • Sequence Length

    • 43
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: Listeria monocytogenes, Lactobacillus salivarius, L. sake, Leuconostoc paramesenteroides, Leuconostoc mesenteroides, Carnobacterium piscicola, Pediococcus dextrinicus, P. pentosaseus, Enterococcus faecalis, E. hirae, Listeria inocua, Clostridium botulinum.
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • DRAMP00076 helical wheel diagram
    • Formula

    • C186H291N55O58S2
    • Absent Amino Acids

    • EFHMPQR
    • Common Amino Acids

    • G
    • Mass

    • 5039.17
    • PI

    • 9.81
    • Basic Residues

    • 5
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 14
    • Boman Index

    • -31.82
    • Hydrophobicity

    • -0.254
    • Aliphatic Index

    • 63.72
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 14105
    • Absorbance 280nm

    • 335.83
    • Polar Residues

    • 23

DRAMP00076

DRAMP00076 chydropathy plot
    • Function

    • This bacteriocin inhibits the growth of a wide range of Gram-positive bacteria at nanomolar concentrations, especially pathogenic L. monocytogenes and C. botulinum but has no effect on the growth of a number of yeasts and Gram-negative bacteria.
    • Biophysicochemical properties

    • pH dependence (Stable from pH 1 to 10); Temperature dependence (Thermostable; Retains 100% of its maximal activity after heating at 100 degrees Celsius for 15 min, but only 50% of activity after heating 1 hour at this same temperature).
  • ·Literature 1
    • Title

    • A novel bacteriocin with a YGNGV motif from vegetable-associated Enterococcus mundtii: full characterization and interaction with target organisms.
    • Reference

    • Biochim Biiophys Acta 1998; 1373: 47-58.
    • Author

    • Bennik MHJ et al Smid EJ.