General Information

    • DRAMP ID

    • DRAMP00076

    • Peptide Name

    • Mundticin ATO6 (Bacteriocin)

    • Source

    • Enterococcus mundtii ATO6 (Gram-positive bacteria)

    • Family

    • Belongs to the class IIa bacteriocin

    • Gene

    • Not found

    • Sequence

    • KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWSK

    • Sequence Length

    • 43

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Listeria monocytogenes, Lactobacillus salivarius, L. sake, Leuconostoc paramesenteroides, Leuconostoc mesenteroides, Carnobacterium piscicola, Pediococcus dextrinicus, P. pentosaseus, Enterococcus faecalis, E. hirae, Listeria inocua, Clostridium botulinum.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00076 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00076.

Physicochemical Information

    • Formula

    • C186H291N55O58S2

    • Absent Amino Acids

    • EFHMPQR

    • Common Amino Acids

    • G

    • Mass

    • 4289.81

    • PI

    • 9.45

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +4

    • Boman Index

    • -31.82

    • Hydrophobicity

    • -0.254

    • Aliphatic Index

    • 63.72

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 14105

    • Absorbance 280nm

    • 335.83

    • Polar Residues

    • 23

DRAMP00076

DRAMP00076 chydropathy plot

Comments Information

    • Function

    • This bacteriocin inhibits the growth of a wide range of Gram-positive bacteria at nanomolar concentrations, especially pathogenic L. monocytogenes and C. botulinum but has no effect on the growth of a number of yeasts and Gram-negative bacteria.

    • Biophysicochemical properties

    • pH dependence (Stable from pH 1 to 10); Temperature dependence (Thermostable; Retains 100% of its maximal activity after heating at 100 degrees Celsius for 15 min, but only 50% of activity after heating 1 hour at this same temperature).

Literature Information

  • ·Literature 1

    • Title

    • A novel bacteriocin with a YGNGV motif from vegetable-associated Enterococcus mundtii: full characterization and interaction with target organisms.

    • Reference

    • Biochim Biiophys Acta 1998; 1373: 47-58.

    • Author

    • Bennik MHJ et al Smid EJ.