General Information

    • DRAMP ID

    • DRAMP00077

    • Peptide Name

    • Mundticin KS (Bacteriocin)

    • Source

    • Enterococcus mundtii NFRI 7393 (Gram-positive bacteria)

    • Family

    • Belongs to the class IIa bacteriocin

    • Gene

    • Not found

    • Sequence

    • KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWKS

    • Sequence Length

    • 43

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Enterococcus faecium IFO13712 (+++), Enterococcus faecalis IFO12964 (+++), Enterococcus mundtii JCM 8731 (+++), Lactobacillus plantarum ATCC 8041 (+), Lactobacillus lactis NFRI 7307 (+), Lactobacillus curvatus JCM 1096 (+), Listeria monocytogenes ATCC 15313 and ATCC 49594 (++).
      • Note: Symbols: +, sensitive to mundticin KS (+, ++, and +++ reflect the degree of sensitivity).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00077 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C186H291N55O58S2

    • Absent Amino Acids

    • EFHMPQR

    • Common Amino Acids

    • G

    • Mass

    • 4289.81

    • PI

    • 9.45

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +4

    • Boman Index

    • -31.82

    • Hydrophobicity

    • -0.254

    • Aliphatic Index

    • 63.72

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 14105

    • Absorbance 280nm

    • 335.83

    • Polar Residues

    • 23

DRAMP00077

DRAMP00077 chydropathy plot

Comments Information

    • Function

    • Mundticin KS is active against closely related lactic acid bacteria and the food-borne pathogen Listeria monocytogenes.

    • Sequence similarity

    • Mundticin KS comprises a 43-amino-acid peptide with an amino acid sequence similar to that of mundticin ATO6 produced by E. mundtii ATO6. Mundticin KS and mundticin ATO6 are distinguished by the inversion of the last two amino acids at their respective C termini.

Literature Information

  • ·Literature 1

    • Title

    • Biochemical and genetic characterization of munddticin KS, an antilisterial peptide produced by Enterococcus mundtii NFRI 7397.

    • Reference

    • Appl Environ Microbiol. 2002 Aug;68(8):3830-3840.

    • Author

    • Kawamoto S, Shima J, Sato R, Eguchi T, Ohmomo S, Shibato J, Horikoshi N, Takeshita K, Sameshima T.