General Information

    • DRAMP ID

    • DRAMP00099

    • Peptide Name

    • Sakacin 5X (Sak5X; Pediocin-like peptide; Bacteriocin)

    • Source

    • lactic acid bacteria (Gram-positive bacteria)

    • Family

    • Belongs to the class IIa bacteriocin

    • Gene

    • Not found

    • Sequence

    • KYYGNGLSCNKSGCSVDWSKAISIIGNNAVANLTTGGAAGWKS

    • Sequence Length

    • 43

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Lactobacillus lactis 105, L. collinoides 110, L. brevis 111, L. brevis 112, Pediococcus damnosus 113, P. damnosus 114, Enterococcus faecalis 109.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00099 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00099.

Physicochemical Information

    • Formula

    • C189H296N54O61S2

    • Absent Amino Acids

    • EFHMPQR

    • Common Amino Acids

    • G

    • Mass

    • 4364.87

    • PI

    • 9.19

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +3

    • Boman Index

    • -34.41

    • Hydrophobicity

    • -0.151

    • Aliphatic Index

    • 70.47

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 14105

    • Absorbance 280nm

    • 335.83

    • Polar Residues

    • 24

DRAMP00099

DRAMP00099 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • An analysis of bacteriocins produced by lactic acid bacteria isolated from malted barley

    • Reference

    • J Appl Microbiol. 2001 Jul;91(1):131-138.

    • Author

    • Vaughan A, Eijsink VG, O'Sullivan TF, O'Hanlon K, van Sinderen D.