General Information

    • DRAMP ID

    • DRAMP00212

    • Peptide Name

    • Rhamnosin A (Bacteriocin)

    • Source

    • Lactobacillus rhamnosus strain 68 (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AVPAVRKTNETLD

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Micrococcus lysodeikticus ATCC 4698.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00212 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00212.

Physicochemical Information

    • Formula

    • C60H104N18O21

    • Absent Amino Acids

    • CFGHIMQSWY

    • Common Amino Acids

    • ATV

    • Mass

    • 1413.59

    • PI

    • 6.11

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • 0

    • Boman Index

    • -31.16

    • Hydrophobicity

    • -0.469

    • Aliphatic Index

    • 90

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP00212

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive bacterium

    • Classification

    • Being a small, heat-stable, nonlanthionine-containing peptide, rhamnosin A should be categorized as a class II bacteriocin.

Literature Information

  • ·Literature 1

    • Title

    • The identification of a low molecular mass bacteriocin, rhamnosin A, produced by Lactobacillus rhamnosus strain 68.

    • Reference

    • J Appl Microbiol. 2009 Dec 1;107(6):2108-2015.

    • Author

    • Dimitrijević R, Stojanović M, Zivković I, Petersen A, Jankov RM, Dimitrijević L, Gavrović-Jankulović M.