General Information

    • DRAMP ID

    • DRAMP00224

    • Peptide Name

    • BTL (Bacteriocin)

    • Source

    • Bacillus subtilis B-TL2 (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KQQLATEAESAGPIL

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Bipolaris maydis, Alternaria brassicae, Aspergillus niger, Cercospora personata.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00224 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00224.

Physicochemical Information

    • Formula

    • C67H114N18O24

    • Absent Amino Acids

    • CDFHMNRVWY

    • Common Amino Acids

    • A

    • Mass

    • 1555.75

    • PI

    • 4.53

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -1

    • Boman Index

    • -15.09

    • Hydrophobicity

    • -0.26

    • Aliphatic Index

    • 98

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP00224

Comments Information

    • Function

    • The peptide exhibits strong inhibitory activity against mycelial growth of Bipolaris maydis, Alternaria brassicae, Aspergillus niger, Cercospora personata.

    • Biophysicochemical properties

    • The purified BTL displays thermostability, almost retaining 100% activity at 100 degrees C for 15 min.

Literature Information

  • ·Literature 1

    • Title

    • A novel small antifungal peptide from Bacillus strain B-TL2 isolated from tobacco stems.

    • Reference

    • Peptides. 2008 Mar;29(3):350-355.

    • Author

    • Zhang B, Xie C, Yang X.