General Information

    • DRAMP ID

    • DRAMP00254

    • Peptide Name

    • Propionicin-F (Bacteriocin)

    • Source

    • Propionibacterium freudenreichii subsp. Freudenreichii LMGT 2946 (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • pcfA

    • Sequence

    • WFYQGMNIAIYANIGGVANIIGYTEAAVATLLGAVVAVAPVVP

    • Sequence Length

    • 43

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Propionibacterium freudenreichii ssp. freudenreichii ATCC 6207T (MIC=0.7 nM), P. freudenreichii ssp.shermanii ATCC 9614T (MIC=5.0 nM), P. freudenreichii ATCC 9616 (MIC=20 nM), P. freudenreichii IFO12426 (MIC=2.5 nM), P. freudenreichii LMGT 2842 (MIC=5.0 nM), P. freudenreichii LMGT 3001 (MIC=5.0 nM), P. freudenreichii LMGT 2946, P. freudenreichii LMGT 2956, P. freudenreichii ISU-P24 (MIC=0.7 nM), P. freudenreichii ISU-P59 (MIC=2.5 nM), P. freudenreichii ISU-P83 (MIC=5.0 nM), P. freudenreichii ISU-P98 (MIC=1.3 nM), P. freudenreichii ISU-P104 (MIC=0.2 nM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00254 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00254.

Physicochemical Information

    • Formula

    • C206H318N48O55S

    • Absent Amino Acids

    • CDHKRS

    • Common Amino Acids

    • A

    • Mass

    • 4379.14

    • PI

    • 4

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 25

    • Net Charge

    • -1

    • Boman Index

    • 53.54

    • Hydrophobicity

    • 1.198

    • Aliphatic Index

    • 131.63

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 9970

    • Absorbance 280nm

    • 237.38

    • Polar Residues

    • 13

DRAMP00254

DRAMP00254 chydropathy plot

Comments Information

    • Function

    • Bacteriocin with specific antibacterial activity.

Literature Information

  • ·Literature 1

    • Title

    • Molecular and genetic characterization of propionicin F, a bacteriocin from Propionibacterium freudenreichii.

    • Reference

    • Appl Environ Microbiol. 2004 Dec;70(12):7303-7310.

    • Author

    • Brede DA, Faye T, Johnsborg O, Odeg¥rd I, Nes IF, Holo H.