• DRAMP ID

    • DRAMP00336
    • Peptide Name

    • ChaC7 (Chassatide C7; uncyclotides; Plant defensin)
    • Source

    • Chassalia chartacea
    • Family

    • Unknow
    • Gene

    • Unknow
    • Sequence

    • IPCGESCVWIPCITAIAGCSCKNKVCYT
    • Sequence Length

    • 28
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknow
    • Biological Activity

    • Unkonw
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=6.4 µM);
      • Gram-positive bacteria: Staphylococcus aureus (MIC>80 µM), Staphylococcus epidermidis (MIC>80 µM).
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP00336 helical wheel diagram
    • Formula

    • C127H204N32O37S6
    • Absent Amino Acids

    • DFHLMQR
    • Common Amino Acids

    • C
    • Mass

    • 3445.37
    • PI

    • 7.73
    • Basic Residues

    • 2
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 9
    • Boman Index

    • 6.64
    • Hydrophobicity

    • 75
    • Aliphatic Index

    • 83.57
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 7365
    • Absorbance 280nm

    • 272.78
    • Polar Residues

    • 14
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Amino Acid Distribution

DRAMP00336 chydropathy plot
    • IC50=1.2 µM, HD50=11.6 µM.

    • Note

    • IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells).
  • Literature 1
    • Reference

    • J Biol Chem. 2012 May 18;287(21):17598-17607.
    • Author

    • Nguyen GK, Lim WH, Nguyen PQ, Tam JP.
    • Title

    • Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.