• DRAMP ID

    • DRAMP00338
    • Peptide Name

    • ChaC11 (Chassatide C11; uncyclotides; Plant defensin)
    • Source

    • Chassalia chartacea
    • Family

    • Unknow
    • Gene

    • Unknow
    • Sequence

    • IPCGESCVWIPCISGMFGCSCKDKVCYS
    • Sequence Length

    • 28
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknow
    • Biological Activity

    • Unkonw
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=8.5 µM);
      • Gram-positive bacteria: Staphylococcus aureus (MIC>80 µM), Staphylococcus epidermidis (MIC>80 µM).
    • Hemolytic activity

    • Unknown
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP00338 helical wheel diagram
    • Formula

    • C129H199N31O38S7
    • Absent Amino Acids

    • AHLNQRT
    • Common Amino Acids

    • C
    • Mass

    • 3498.39
    • PI

    • 6.03
    • Basic Residues

    • 2
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 7
    • Boman Index

    • 0.63
    • Hydrophobicity

    • 60.71
    • Aliphatic Index

    • 62.5
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 7365
    • Absorbance 280nm

    • 272.78
    • Polar Residues

    • 14

Amino Acid Distribution

DRAMP00338 chydropathy plot
    • IC50=1.2 µM, HD50=13.3 µM.

    • Note

    • IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells).
  • Literature 1
    • Reference

    • J Biol Chem. 2012 May 18;287(21):17598-17607.
    • Author

    • Nguyen GK, Lim WH, Nguyen PQ, Tam JP.
    • Title

    • Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.