General Information

    • DRAMP ID

    • DRAMP00375

    • Peptide Name

    • Antifungal protein 1 small subunit (CW-1; Plants)

    • Source

    • Malva parviflora (Little mallow) (Cheeseweed mallow)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • PAGPFRIPPRXRXEFQ

    • Sequence Length

    • 16

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi:
      • At low salt condition: Fusarium graminearum (IC50=2.5 ppm).
      • At high salt condition: Fusarium graminearum (IC50=10 ppm).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00375 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00375.

Physicochemical Information

    • Formula

    • C77H114N24O16

    • Absent Amino Acids

    • CDHKLMNSTVWY

    • Common Amino Acids

    • P

    • Mass

    • 1890.6

    • PI

    • 11.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +2

    • Boman Index

    • -43.48

    • Hydrophobicity

    • -0.963

    • Aliphatic Index

    • 30.63

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP00375

Comments Information

    • Function

    • Possesses very potent antifungal activity against F. graminearum.

    • Subunit structure

    • Heterodimer of a large and a small subunit.

    • Miscellaneous

    • Antimicrobial activity is not affected by salt concentration.

Literature Information

  • ·Literature 1

    • Title

    • Potent heterologous antifungal proteins from cheeseweed (Malva parviflora).

    • Reference

    • Biochem Biophys Res Commun. 2000 Dec 20;279(2):669-673.

    • Author

    • Wang X, Bunkers GJ.