General Information
-
DRAMP ID
- DRAMP00376
-
Peptide Name
- Antifungal protein 1 large subunit (CW-1; Plants)
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Source
- Malva parviflora (Little mallow) (Cheeseweed mallow)
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Family
- Not found
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Gene
- Not found
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Sequence
- VAGPFRIPPLRREFQ
-
Sequence Length
- 15
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UniProt Entry
- P83141
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- Fungi: Phytophthora infestans.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00376.
Physicochemical Information
-
Formula
- C83H131N25O19
Absent Amino Acids
- CDHKMNSTWY
Common Amino Acids
- PR
Mass
- 1783.11
PI
- 11.7
Basic Residues
- 3
Acidic Residues
- 1
Hydrophobic Residues
- 6
Net Charge
- +2
-
Boman Index
- -34.52
Hydrophobicity
- -0.387
Aliphatic Index
- 78
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 1
DRAMP00376
Comments Information
Function
- Possesses antifungal activity against P. infestans but not F. graminearum.
Subunit structure
- Heterodimer of a large and a small subunit.
Miscellaneous
- Antimicrobial activity is not affected by salt concentration.
Literature Information
- ·Literature 1
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Title
- Potent heterologous antifungal proteins from cheeseweed (Malva parviflora).
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Pubmed ID
- 11118343
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Reference
- Biochem Biophys Res Commun. 2000 Dec 20;279(2):669-673.
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Author
- Wang X, Bunkers GJ.