General Information

    • DRAMP ID

    • DRAMP00378

    • Peptide Name

    • Antifungal protein 2 large subunit (CW-2; Plants)

    • Source

    • Malva parviflora (Little mallow) (Cheeseweed mallow)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • PEDPQRRYQEXQREXRXQQE

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Phytophthora infestans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00378 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00378.

Physicochemical Information

    • Formula

    • C92H140N34O31

    • Absent Amino Acids

    • ACFGHIKLMNSTVW

    • Common Amino Acids

    • Q

    • Mass

    • 2606.37

    • PI

    • 5.01

    • Basic Residues

    • 4

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 0

    • Net Charge

    • -1

    • Boman Index

    • -123.48

    • Hydrophobicity

    • -2.875

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 78.42

    • Polar Residues

    • 1

DRAMP00378

DRAMP00378 chydropathy plot

Comments Information

    • Function

    • Possesses antifungal activity against P. infestans but not F. graminearum.

    • Subunit structure

    • Heterodimer of a large and a small subunit.

    • Miscellaneous

    • Antimicrobial activity is not affected by salt concentration.

Literature Information

  • ·Literature 1

    • Title

    • Potent heterologous antifungal proteins from cheeseweed (Malva parviflora).

    • Reference

    • Biochem Biophys Res Commun. 2000 Dec 20;279(2):669-673.

    • Author

    • Wang X, Bunkers GJ.