General Information
-
DRAMP ID
- DRAMP00384
-
Peptide Name
- Cc-GRP (Gly-rich; Plants)
-
Source
- Coffea canephora
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GNEGGGHGGHGGYGGYHHHGGGGGGYGGYHGGGGS
-
Sequence Length
- 35
-
Swiss_Prot Entry
- No entry found
-
Evidence code
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
-
Target Organism
-
- Fungi: Candida albicans (MIC=90 µg/ml), Candida tropicalis (MIC=180 µg/ml), Colletotrichum lindemuthianum (MIC=90 µg/ml), Fusarium oxysporium (MIC=90 µg/ml).
-
Hemolytic Activity
-
- Not found
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Other Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Rich
-
Structure Description
- Not found
-
PDB ID
- None
-
-
Physicochemical Information
-
Formula
- C128H164N48O44
Absent Amino Acids
- ACDFIKLMPQRTVW
Common Amino Acids
- G
Mass
- 3685.66
PI
- 7.18
Basic Residues
- 6
Acidic Residues
- 1
Hydrophobic Residues
- 0
-
Boman Index
- -24.69
Hydrophobicity
- -1.171
Aliphatic Index
- 0
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5960
Absorbance 280nm
- 175.29
Polar Residues
- 28
DRAMP00384

Comments Information
The sequence displayed is only the N-terminal sequence of 7 kD peptide. The peptide was located in the cell wall, cell surface and nucleus of Fusarium oxysporum.
Literature Information
- ·Literature 1
-
Title
- An antifungal peptide from Coffea canephora seeds with sequence homology to glycine-rich proteins exerts membrane permeabilization and nuclear localization in fungi.
-
Pubmed ID
- 23500079
-
Reference
- Biochim Biophys Acta. 2013 Mar 15.[Epub ahead of print]
-
Author
- Zottich U, Da Cunha M, Carvalho AO, Dias GB, Casarin N, Vasconcelos IM, Gomes VM.