General Information

    • DRAMP ID

    • DRAMP00384

    • Peptide Name

    • Cc-GRP (Gly-rich; Plants)

    • Source

    • Coffea canephora

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GNEGGGHGGHGGYGGYHHHGGGGGGYGGYHGGGGS

    • Sequence Length

    • 35

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Candida albicans (MIC=90 µg/ml), Candida tropicalis (MIC=180 µg/ml), Colletotrichum lindemuthianum (MIC=90 µg/ml), Fusarium oxysporium (MIC=90 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00384 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00384.

Physicochemical Information

    • Formula

    • C128H164N48O44

    • Absent Amino Acids

    • ACDFIKLMPQRTVW

    • Common Amino Acids

    • G

    • Mass

    • 3079.01

    • PI

    • 6.62

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 0

    • Net Charge

    • +5

    • Boman Index

    • -24.69

    • Hydrophobicity

    • -1.171

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5960

    • Absorbance 280nm

    • 175.29

    • Polar Residues

    • 28

DRAMP00384

DRAMP00384 chydropathy plot

Comments Information

    • Comment

    • The sequence displayed is only the N-terminal sequence of 7 kD peptide. The peptide was located in the cell wall, cell surface and nucleus of Fusarium oxysporum.

Literature Information

  • ·Literature 1

    • Title

    • An antifungal peptide from Coffea canephora seeds with sequence homology to glycine-rich proteins exerts membrane permeabilization and nuclear localization in fungi.

    • Reference

    • Biochim Biophys Acta. 2013 Mar 15.[Epub ahead of print]

    • Author

    • Zottich U, Da Cunha M, Carvalho AO, Dias GB, Casarin N, Vasconcelos IM, Gomes VM.