General Information
-
DRAMP ID
- DRAMP00423
-
Peptide Name
- Defensin-like protein 2 (Sa-AFP2; Plant defensin)
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Source
- Sinapis alba (White mustard) (Brassica hirta)
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Family
- Not found
-
Gene
- Not found
-
Sequence
- KLCQRPSGTWSGVCGNNNACKNQCINLEKARHGSCNYVFPAHKCICYFPC
-
Sequence Length
- 50
-
Swiss_Prot Entry
- No entry found
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Evidence code
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- Fungi: Alternaria brassicola (MIC=4.5 µg/ml), Botrytis cinerea (MIC=3.5 µg/ml), Fusarium culmorum (MIC=2.3 µg/ml), Fusarium oxysporum f.sp.lycopersici (MIC=2.3 µg/ml), Pyricularia oryzae (MIC=0.3 µg/ml), Verticillium dahliae (MIC=1.2 µg/ml).
- NOTE: In synthetic low ionic strength fungal growth medium.
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Hemolytic Activity
-
- Not found
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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PDB ID
- None
-
-
Physicochemical Information
-
Formula
- C237H365N73O67S8
Absent Amino Acids
- DM
Common Amino Acids
- C
Mass
- 6439.64
PI
- 8.59
Basic Residues
- 8
Acidic Residues
- 1
Hydrophobic Residues
- 12
-
Boman Index
- -76.66
Hydrophobicity
- -0.39
Aliphatic Index
- 48.8
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 8980
Absorbance 280nm
- 183.27
Polar Residues
- 24
DRAMP00423

Comments Information
Function
- Possesses antifungal activity sensitive to inorganic cations.
Literature Information
- ·Literature 1
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Title
- A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species.
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Pubmed ID
- 8422949
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Reference
- FEBS Lett. 1993 Feb 1;316(3):233-240.
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Author
- Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF.