General Information
-
DRAMP ID
- DRAMP00425
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Peptide Name
- Tn-AFP1 (Trapa natans antifungal peptide; Plant defensin)
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Source
- Trapa natans
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Family
- Not found
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Gene
- Not found
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Sequence
- LMCTHPLDCSN
-
Sequence Length
- 11
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Swiss_Prot Entry
- No entry found
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Evidence code
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- Yeast: Candida tropicalis (MIC=32 µg/ml).
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Hemolytic Activity
-
- Not found
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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PDB ID
- None
-
-
Physicochemical Information
-
Formula
- C49H80N14O17S3
Absent Amino Acids
- AEFGIKQRVWY
Common Amino Acids
- CL
Mass
- 1412
PI
- 5.29
Basic Residues
- 1
Acidic Residues
- 1
Hydrophobic Residues
- 2
-
Boman Index
- -11.24
Hydrophobicity
- 0.109
Aliphatic Index
- 70.91
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 12.5
Polar Residues
- 5
DRAMP00425
Comments Information
Function
- Tn-AFP1 has no adverse effect on red blood cells at concentration of 32 μg/mL.
Literature Information
- ·Literature 1
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Title
- Identification of an antifungal peptide from Trapa natans fruits with inhibitory effects on Candida tropicalis biofilm formation.
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Pubmed ID
- 21736910
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Reference
- Peptides. 2011 Aug;32(8):1741-1747.
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Author
- Mandal SM, Migliolo L, Franco OL, Ghosh AK.