General Information
-
DRAMP ID
- DRAMP00437
-
Peptide Name
- Pisum sativum defensin 2 (Psd2; Plant defensin)
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Source
- Pisum sativum (Garden pea)
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Family
- Belongs to the DEFL family
-
Gene
- Not found
-
Sequence
- KTCENLSGTFKGPCIPDGNCNKHCRNNEHLLSGRCRDDFRCWCTNRC
-
Sequence Length
- 47
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Swiss_Prot Entry
- P81930
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Evidence code
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- PD: Aspergillus niger (MIC=10.2 µg/ml), Aspergillus versicolor (MIC=0.34 µg/ml), Fusarium moniliforme (MIC=10.0 µg/ml), Fusarium oxysporum (MIC>100 µg/ml), Fusarium solani (MIC=8.5 µg/ml), Neurospora crassa (MIC<0.5 µg/ml), Saccharomyces cerevisae (MIC>100 µg/ml), Trichophyton mentagrophytes (MIC<100 µg/ml).
- PD+: Aspergillus niger (MIC=7.8 µg/ml), Aspergillus versicolor (MIC=5.9 µg/ml), Fusarium moniliforme (MIC=25 µg/ml), Fusarium oxysporum (MIC>100 µg/ml), Fusarium solani (MIC=5.0 µg/ml).
- NOTE: PD+ = potato dextrose medium supplemented with 1 mM CaCl2.
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Hemolytic Activity
-
- Not found
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
-
Structure Description
- Not found
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PDB ID
- None
-
-
Physicochemical Information
-
Formula
- C219H346N76O69S8
Absent Amino Acids
- AMQVY
Common Amino Acids
- C
Mass
- 6224.79
PI
- 8.22
Basic Residues
- 10
Acidic Residues
- 5
Hydrophobic Residues
- 7
-
Boman Index
- -152.73
Hydrophobicity
- -1
Aliphatic Index
- 33.19
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 6000
Absorbance 280nm
- 130.43
Polar Residues
- 23
DRAMP00437

Comments Information
PTM
- Contains four disulfide bonds 3-47; 14-35; 20-41; 24-43.
Literature Information
- ·Literature 1
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Title
- Characterization of two novel defense peptides from pea (Pisum sativum) seeds.
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Pubmed ID
- 10860545
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Reference
- Arch Biochem Biophys. 2000 Jun 15;378(2):278-286.
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Author
- Almeida M.S, Cabral K.M, Zingali R.B, Kurtenbach E.