General Information
-
DRAMP ID
- DRAMP00455
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Peptide Name
- Defensin-like protein 2 (Fabatin-2; Plant defensin)
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Source
- Vicia faba (Broad bean)
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Family
- Belongs to the DEFL family
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Gene
- Not found
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Sequence
- LLGRCKVKSNRFNGPCLTDTHCSTVCRGEGYKGGDCHGLRRRCMCLC
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Sequence Length
- 47
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UniProt Entry
- P81457
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: Bacillus subtilis, Enterococcus hirae;
- Gram-negative bacterium: Pseudomonas aeruginosa.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Cell membrane
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00455.
Physicochemical Information
-
Formula
- C211H352N74O62S9
Absent Amino Acids
- AIQW
Common Amino Acids
- C
Mass
- 5206.11
PI
- 9.12
Basic Residues
- 11
Acidic Residues
- 3
Hydrophobic Residues
- 8
Net Charge
- +8
-
Boman Index
- -112.84
Hydrophobicity
- -0.423
Aliphatic Index
- 53.83
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 1990
Absorbance 280nm
- 43.26
Polar Residues
- 23
DRAMP00455
Comments Information
Function
- Fabatins have antibacterial activity against Gram-positive and Gram-negative bacteria, but were inactive against the yeasts Saccharomyces cerevisiae and Candida albicans. High activity against P. aeruginosa.
PTM
- Contains four disulfide bonds 5-47; 16-36; 22-43; 26-45.
Literature Information
- ·Literature 1
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Title
- Fabatins: new antimicrobial plant peptides.
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Pubmed ID
- 9103978
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Reference
- FEMS Microbiol Lett. 1997 Apr 1;149(1):59-64.
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Author
- Zhang Y, Lewis K.