• DRAMP ID

    • DRAMP00765
    • Peptide Name

    • Piceain 2 (Plants)
    • Source

    • Picea sitchensis
    • Family

    • Unknow
    • Gene

    • Unknow
    • Sequence

    • RPRCWIKIKFRCKSLKF
    • Sequence Length

    • 17
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknow
    • Biological Activity

    • Antibacterial, Antifungal
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 µg/ml), S. aureus ATCC 43300 (MIC=18.75 µg/ml);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=37.5 µg/ml), Escherichia coli ML-35P (MIC=37.5 µg/ml), Escherichia coli 08040722 (CI) (MIC=75 µg/ml), Escherichia coli 08A866 (CI) (MIC=37.5 µg/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 µg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=18.75 µg/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 µg/ml).
      • Yeast: Candida albicans ATCC 20032 (MIC=18.75 µg/ml).
    • Hemolytic activity

    • Unknown
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP00765 helical wheel diagram
    • Formula

    • C103H169N31O19S2
    • Absent Amino Acids

    • ADEGHMNQTVY
    • Common Amino Acids

    • K
    • Mass

    • 2495.35
    • PI

    • 11.72
    • Basic Residues

    • 7
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Boman Index

    • -44.75
    • Hydrophobicity

    • -52.94
    • Aliphatic Index

    • 68.82
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 351.56
    • Polar Residues

    • 3

DRAMP00765

    • Function

    • Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells.
    • PTM

    • Contains one disulfide bond.
  • Literature 1
    • Reference

    • J Pept Sci. 2011 Sep;17(9):627-631.
    • Author

    • Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R.
    • Title

    • Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis.