• DRAMP ID

    • DRAMP00778
    • Peptide Name

    • Viphi E (Plants)
    • Source

    • Viola philippica
    • Family

    • Belongs to the cyclotide family
    • Gene

    • Not found
    • Sequence

    • GSIPCGESCVFIPCISAVIGCSCSNKVCYKN
    • Sequence Length

    • 31
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Anti-cancer
    • Target Organism

      • Cancer cell lines: MM96L (IC50=2.51±0.03 µM), HeLa (IC50=5.24±0.40 µM).
      • Non-Cancer cell line: HFF-1 (IC50=1.55±0.09 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00778 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00778.
    • Formula

    • C134H217N35O42S6
    • Absent Amino Acids

    • DHLMQRTW
    • Common Amino Acids

    • C
    • Mass

    • 3182.77
    • PI

    • 7.77
    • Basic Residues

    • 2
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +1
    • Boman Index

    • -1.24
    • Hydrophobicity

    • 0.716
    • Aliphatic Index

    • 81.61
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1865
    • Absorbance 280nm

    • 62.17
    • Polar Residues

    • 17

DRAMP00778

DRAMP00778 chydropathy plot
    • Function

    • The novel cyclotides show cytotoxic activity against several cancer cell lines. Note
  • ·Literature 1
    • Title

    • Isolation and characterization of cytotoxic cyclotides from Viola philippica.
    • Reference

    • Peptides. 2011 Aug;32(8):1719-1723.
    • Author

    • He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N.