General Information
-
DRAMP ID
- DRAMP00787
-
Peptide Name
- Varv peptide D (Varv D; Plant defensin)
-
Source
- Viola arvensis (European field pansy) (Field violet)
-
Family
- Belongs to the cyclotide family
-
Gene
- Not found
-
Sequence
- GLPICGETCVGGSCNTPGCSCSWPVCTRN
-
Sequence Length
- 29
-
UniProt Entry
- P58449
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Anti-cancer
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00787.
Physicochemical Information
-
Formula
- C116H185N35O40S6
Absent Amino Acids
- ADFHKMQY
Common Amino Acids
- C
Mass
- 2902.32
PI
- 5.96
Basic Residues
- 1
Acidic Residues
- 1
Hydrophobic Residues
- 5
Net Charge
- 0
-
Boman Index
- -20.29
Hydrophobicity
- 0.155
Aliphatic Index
- 46.9
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5875
Absorbance 280nm
- 209.82
Polar Residues
- 19
DRAMP00787
Comments Information
Function
- Probably participates in a plant defense mechanism.
PTM
- Contains three disulfide bonds 5-19; 9-21; 14-26.
Literature Information
- ·Literature 1
-
Title
- Seven novel macrocyclic polypeptides from Viola arvensis.
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Pubmed ID
- 10075760
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Reference
- J Nat Prod. 1999 Feb;62(2):283-286.
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Author
- Göransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P.