General Information
-
DRAMP ID
- DRAMP00894
-
Peptide Name
- Cyclotide hyfl-K (Plant defensin)
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Source
- Hybanthus floribundus (Greenviolet)
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Family
- Belongs to the cyclotide family
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Gene
- Not found
-
Sequence
- GTPCGESCVYIPCFTAVVGCTCKDKVCYLN
-
Sequence Length
- 30
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Not found
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
-
Structure Description
- Cyclotides are plant-derived miniproteins that have the unusual features of a head-to-tail cyclized peptide backbone and a knotted arrangement of disulfide bonds.
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00894.
Physicochemical Information
-
Formula
- C136H213N33O42S6
Absent Amino Acids
- HMQRW
Common Amino Acids
- C
Mass
- 3174.74
PI
- 6.03
Basic Residues
- 2
Acidic Residues
- 2
Hydrophobic Residues
- 8
Net Charge
- 0
-
Boman Index
- -3.37
Hydrophobicity
- 0.55
Aliphatic Index
- 68
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 115.69
Polar Residues
- 16
DRAMP00894
Comments Information
Function
- Probably participates in a plant defense mechanism.
Literature Information
- ·Literature 1
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Title
- A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae).
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Pubmed ID
- 16199617
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Reference
- Plant Cell. 2005 Nov;17(11):3176-3189.
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Author
- Simonsen SM, Sando L, Ireland DC, Colgrave ML, Bharathi R, Göransson U, Craik DJ.