General Information

    • DRAMP ID

    • DRAMP00952

    • Peptide Name

    • Viscotoxin A1 (Plant defensin)

    • Source

    • Viscum album (European mistletoe)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KSCCPNTTGRNIYNTCRLTGSSRETCAKLSGCKIISASTCPSNYPK

    • Sequence Length

    • 46

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Antiviral

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Combine helix and strand structure

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00952 helical wheel diagram

    • PDB ID

    • 3C8P resolved by X-ray.
  • 3C8P-> 

    • Predicted Structure

    • There is no predicted structure for DRAMP00952.

Physicochemical Information

    • Formula

    • C201H337N63O68S6

    • Absent Amino Acids

    • DFHMQVW

    • Common Amino Acids

    • S

    • Mass

    • 4916.63

    • PI

    • 9.3

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +6

    • Boman Index

    • -101.11

    • Hydrophobicity

    • -0.55

    • Aliphatic Index

    • 46.74

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 3355

    • Absorbance 280nm

    • 74.56

    • Polar Residues

    • 28

DRAMP00952

DRAMP00952 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone.

    • Reference

    • Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):985-992.

    • Author

    • Pal A, Debreczeni JE, Sevvana M, Gruene T, Kahle B, Zeeck A, Sheldrick GM.