General Information

    • DRAMP ID

    • DRAMP00956

    • Peptide Name

    • Viscotoxin-C1 (VtC1; Plant defensin)

    • Source

    • Viscum album (European mistletoe)

    • Family

    • Belongs to the thionin family

    • Gene

    • Not found

    • Sequence

    • KSCCPNTTGRNIYNTCRFAGGSRERCAKLSGCKIISASTCPSDYPK

    • Sequence Length

    • 46

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Cytotoxic

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Combine helix and strand structure

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00956 helical wheel diagram

    • PDB ID

    • 1ORL resolved by NMR. 3C8P resolved by X-ray.
  • 1ORL-> 
    3C8P-> 

    • Predicted Structure

    • There is no predicted structure for DRAMP00956.

Physicochemical Information

    • Formula

    • C204H335N65O66S6

    • Absent Amino Acids

    • HMQVW

    • Common Amino Acids

    • CS

    • Mass

    • 4946.66

    • PI

    • 9.3

    • Basic Residues

    • 8

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +6

    • Boman Index

    • -108.76

    • Hydrophobicity

    • -0.591

    • Aliphatic Index

    • 40.43

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 3355

    • Absorbance 280nm

    • 74.56

    • Polar Residues

    • 25

DRAMP00956

DRAMP00956 chydropathy plot

Comments Information

    • Function

    • Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise Function

    • PTM

    • Contains three disulfide bonds 3-40; 4-32; 16-26.

Literature Information

  • ·Literature 1

    • Title

    • Amino acid sequence, S-S bridge arrangement and distribution in plant tissues of thionins from Viscum album.

    • Reference

    • Biol Chem. 1997 Sep;378(9):989-996.

    • Author

    • Orr¹ S, Scaloni A, Giannattasio M, Urech K, Pucci P, Schaller G.
  • ·Literature 2

    • Title

    • NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-Function: analysis of viscotoxins.

    • Reference

    • Biochemistry. 2003 Nov 4;42(43):12503-10.

    • Author

    • Romagnoli S, Fogolari F, Catalano M, Zetta L, Schaller G, Urech K, Giannattasio M, Ragona L, Molinari H.