• DRAMP ID

    • DRAMP00978
    • Peptide Name

    • Antifungal peptide 1 (EAFP1; Plant defensin)
    • Source

    • Eucommia ulmoides (Hardy rubber tree)
    • Family

    • Belongs to the hevein-like family
    • Gene

    • N/A
    • Sequence

    • QTCASRCPRPCNAGLCCSIYGYCGSGNAYCGAGNCRCQCRG
    • Sequence Length

    • 41
    • Evidence code

    • Protein level
    • Biological Activity

    • Antifungal, Antimicrobial
    • Target Organism

      • Fungi: Phytophthora infestans, Ascochyta lycopersici (IC50=155 µg/ml), Verticillium dahliae, Gibberella zeae, Alternaria nicotianae, Fusarium moniliforme (IC50=56 µg/ml), Fusarium oxysporum (IC50=46 µg/ml) and Colletotrichum gossypii (IC50=35 µg/ml).
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Chitin-binding
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • N/A
    • DRAMP00978 helical wheel diagram
    • Formula

    • C164H260N58O54S10
    • Absent Amino Acids

    • DEFHKMVW
    • Common Amino Acids

    • C
    • Mass

    • 4942.51
    • PI

    • 8.26
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Boman Index

    • -67.41
    • Hydrophobicity

    • -19.51
    • Aliphatic Index

    • 28.78
    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5095
    • Absorbance 280nm

    • 127.38
    • Polar Residues

    • 27

DRAMP00978

DRAMP00978 chydropathy plot
    • Function

    • Has antifungal activity. PTM
  • Literature 1
    • Title

    • Two novel antifungal peptides distinct with a five-disulfide motif from the bark of Eucommia ulmoides Oliv.
    • Reference

    • FEBS Lett. 2002 Jun 19;521(1-3):87-90.
    • Author

    • Huang R.-H, Xiang Y, Liu X.-Z, Zhang Y, Hu Z, Wang D.-C.