General Information

    • DRAMP ID

    • DRAMP00978

    • Peptide Name

    • Antifungal peptide 1 (EAFP1; Plant defensin)

    • Source

    • Eucommia ulmoides (Hardy rubber tree)

    • Family

    • Belongs to the hevein-like family

    • Gene

    • Not found

    • Sequence

    • QTCASRCPRPCNAGLCCSIYGYCGSGNAYCGAGNCRCQCRG

    • Sequence Length

    • 41

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Phytophthora infestans, Ascochyta lycopersici (IC50=155 µg/ml), Verticillium dahliae, Gibberella zeae, Alternaria nicotianae, Fusarium moniliforme (IC50=56 µg/ml), Fusarium oxysporum (IC50=46 µg/ml) and Colletotrichum gossypii (IC50=35 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Chitin-binding

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00978 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00978.

Physicochemical Information

    • Formula

    • C164H260N58O54S10

    • Absent Amino Acids

    • DEFHKMVW

    • Common Amino Acids

    • C

    • Mass

    • 4228.82

    • PI

    • 8.62

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -67.41

    • Hydrophobicity

    • -0.195

    • Aliphatic Index

    • 28.78

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5095

    • Absorbance 280nm

    • 127.38

    • Polar Residues

    • 27

DRAMP00978

DRAMP00978 chydropathy plot

Comments Information

    • Function

    • Has antifungal activity. PTM

Literature Information

  • ·Literature 1

    • Title

    • Two novel antifungal peptides distinct with a five-disulfide motif from the bark of Eucommia ulmoides Oliv.

    • Reference

    • FEBS Lett. 2002 Jun 19;521(1-3):87-90.

    • Author

    • Huang R.-H, Xiang Y, Liu X.-Z, Zhang Y, Hu Z, Wang D.-C.