• DRAMP ID

    • DRAMP00988
    • Peptide Name

    • Ee-CBPl (Hevein-like antimicrobial peptide; Plants)
    • Source

    • Euonymus europaeus (European spindle tree)
    • Family

    • Belongs to the hevein-like family
    • Gene

    • N/A
    • Sequence

    • QQCGRQAGNRRCPNNLCCSQFGYCGRTNEYCCTGFGCQSNCRRCG
    • Sequence Length

    • 45
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • N/A
    • Biological Activity

    • Antifungal, Antimicrobial
    • Target Organism

      • Fungi: Alternaria brassicicola (IC50=0.6 µM), Botrytis cinerea (IC50=0.2 µM), Fusarium culmorum (IC50=0.6 µM), Fusarium oxysporum f. sp. cubense (IC50=3 µM), Fusarium oxysporum f. sp. matthiolae (IC50=1 µM), Mycosphaerella eumusae (IC50=1.2 µM), Neurospora crassa (IC50=0.4 µM), Phoma exigua (IC50=6.6 µM),Phytophthora cryptogea (IC50=5 µM), Pythium ultimum (IC50=6.6 µM), Rhizoctonia solani (IC50=5 µM), Trichoderma hamatum (IC50=20 µM).
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Chitin-binding
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • N/A
    • Structure Description

    • N/A
    • DRAMP00988 helical wheel diagram
    • Formula

    • C194H305N73O64S10
    • Absent Amino Acids

    • DHIKMVW
    • Common Amino Acids

    • C
    • Mass

    • 5789.62
    • PI

    • 8.42
    • Basic Residues

    • 6
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 4
    • Boman Index

    • -137.38
    • Hydrophobicity

    • -87.33
    • Aliphatic Index

    • 10.89
    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 3605
    • Absorbance 280nm

    • 81.93
    • Polar Residues

    • 28

DRAMP00988

DRAMP00988 chydropathy plot
    • Function

    • Ee-CBP1 possesses a very strong antifungal activity.
    • PTM

    • Contains Disulfide bond.
  • Literature 1
    • Title

    • Synergistic antifungal activity of two chitin-binding proteins from spindle tree (Euonymus europaeus L.).
    • Reference

    • Planta. 2004 Jun;219(2):221-232.
    • Author

    • Van den Bergh KP, Roug© P, Proost P, Coosemans J, Krouglova T, Engelborghs Y, Peumans WJ, Van Damme EJ.