General Information

    • DRAMP ID

    • DRAMP00988

    • Peptide Name

    • Ee-CBPl (Hevein-like antimicrobial peptide; Plants)

    • Source

    • Euonymus europaeus (European spindle tree)

    • Family

    • Belongs to the hevein-like family

    • Gene

    • Not found

    • Sequence

    • QQCGRQAGNRRCPNNLCCSQFGYCGRTNEYCCTGFGCQSNCRRCG

    • Sequence Length

    • 45

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Alternaria brassicicola (IC50=0.6 µM), Botrytis cinerea (IC50=0.2 µM), Fusarium culmorum (IC50=0.6 µM), Fusarium oxysporum f. sp. cubense (IC50=3 µM), Fusarium oxysporum f. sp. matthiolae (IC50=1 µM), Mycosphaerella eumusae (IC50=1.2 µM), Neurospora crassa (IC50=0.4 µM), Phoma exigua (IC50=6.6 µM),Phytophthora cryptogea (IC50=5 µM), Pythium ultimum (IC50=6.6 µM), Rhizoctonia solani (IC50=5 µM), Trichoderma hamatum (IC50=20 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Chitin-binding

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00988 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00988.

Physicochemical Information

    • Formula

    • C194H305N73O64S10

    • Absent Amino Acids

    • DHIKMVW

    • Common Amino Acids

    • C

    • Mass

    • 5004.61

    • PI

    • 8.81

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +5

    • Boman Index

    • -137.38

    • Hydrophobicity

    • -0.873

    • Aliphatic Index

    • 10.89

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 3605

    • Absorbance 280nm

    • 81.93

    • Polar Residues

    • 28

DRAMP00988

DRAMP00988 chydropathy plot

Comments Information

    • Function

    • Ee-CBP1 possesses a very strong antifungal activity.

    • PTM

    • Contains Disulfide bond.

Literature Information

  • ·Literature 1

    • Title

    • Synergistic antifungal activity of two chitin-binding proteins from spindle tree (Euonymus europaeus L.).

    • Reference

    • Planta. 2004 Jun;219(2):221-232.

    • Author

    • Van den Bergh KP, Roug© P, Proost P, Coosemans J, Krouglova T, Engelborghs Y, Peumans WJ, Van Damme EJ.