• DRAMP ID

    • DRAMP00990
    • Peptide Name

    • Sm-AMP-D1 (Plant defensin)
    • Source

    • Stellaria media L (Common chickweed seeds)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • KICERASGTWKGICIHSNDCNNQCVKWENAGSGSCHYQFPNYMCFCYFDC
    • Sequence Length

    • 50
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antifungal
    • Target Organism

      • Fungi: Fusarium oxysporum 16/10 (IC50=0.5 µM), Botrytis cinerea SGR-1 (IC50=0.35 µM), Bipolaris sorokiniana 6/10 (IC50=0.52 µM), Fusarium graminearum VKM F-1668 (IC50=0.52 µM), Fusarium avenaceum VKM F-2303 (IC50=1 µM), Phoma betae VKM F-2532 (IC50=0.52 µM), Pythium debaryanum VKMF-1505 (IC50=1 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00990 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00990.
    • Formula

    • C247H355N69O74S9
    • Absent Amino Acids

    • L
    • Common Amino Acids

    • C
    • Mass

    • 5763.49
    • PI

    • 6.86
    • Basic Residues

    • 6
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +2
    • Boman Index

    • -80.45
    • Hydrophobicity

    • -0.446
    • Aliphatic Index

    • 33.2
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 15970
    • Absorbance 280nm

    • 325.92
    • Polar Residues

    • 25

DRAMP00990

DRAMP00990 chydropathy plot
    • Function

    • Sm-AMP-D defensins displays strong antifungal activity against important plant pathogens being active at very low concentrations (IC50=1 M).
  • ·Literature 1
    • Title

    • Isolation, molecular cloning and antimicrobial activity of novel defensins from common chickweed (Stellaria media L.) seeds.
    • Reference

    • Biochimie. 2011 Mar;93(3):450-456.
    • Author

    • Slavokhotova AA, Odintsova TI, Rogozhin EA, Musolyamov AK, Andreev YA, Grishin EV, Egorov TA.