General Information
-
DRAMP ID
- DRAMP00990
-
Peptide Name
- Sm-AMP-D1 (Plant defensin)
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Source
- Stellaria media L (Common chickweed seeds)
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Family
- Not found
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Gene
- Not found
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Sequence
- KICERASGTWKGICIHSNDCNNQCVKWENAGSGSCHYQFPNYMCFCYFDC
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Sequence Length
- 50
-
UniProt Entry
- No entry found
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Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- Fungi: Fusarium oxysporum 16/10 (IC50=0.5 µM), Botrytis cinerea SGR-1 (IC50=0.35 µM), Bipolaris sorokiniana 6/10 (IC50=0.52 µM), Fusarium graminearum VKM F-1668 (IC50=0.52 µM), Fusarium avenaceum VKM F-2303 (IC50=1 µM), Phoma betae VKM F-2532 (IC50=0.52 µM), Pythium debaryanum VKMF-1505 (IC50=1 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00990.
Physicochemical Information
-
Formula
- C247H355N69O74S9
Absent Amino Acids
- L
Common Amino Acids
- C
Mass
- 5763.49
PI
- 6.86
Basic Residues
- 6
Acidic Residues
- 4
Hydrophobic Residues
- 11
Net Charge
- +2
-
Boman Index
- -80.45
Hydrophobicity
- -0.446
Aliphatic Index
- 33.2
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 15970
Absorbance 280nm
- 325.92
Polar Residues
- 25
DRAMP00990
Comments Information
Function
- Sm-AMP-D defensins displays strong antifungal activity against important plant pathogens being active at very low concentrations (IC50=1 M).
Literature Information
- ·Literature 1
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Title
- Isolation, molecular cloning and antimicrobial activity of novel defensins from common chickweed (Stellaria media L.) seeds.
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Pubmed ID
- 21056078
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Reference
- Biochimie. 2011 Mar;93(3):450-456.
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Author
- Slavokhotova AA, Odintsova TI, Rogozhin EA, Musolyamov AK, Andreev YA, Grishin EV, Egorov TA.