General Information

    • DRAMP ID

    • DRAMP01009

    • Peptide Name

    • Alliumin (Plants)

    • Source

    • Allium sativum (Garlic)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DDFLCAGGCL

    • Sequence Length

    • 10

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antifungal

    • Target Organism

      • Fungi: Mycosphaerella arachidicola (IC50=1.3 µM).
      • Gram-negative bacterium: Pseudomonas fluorescens.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01009 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01009.

Physicochemical Information

    • Formula

    • C42H64N10O15S2

    • Absent Amino Acids

    • EHIKMNPQRSTVWY

    • Common Amino Acids

    • CDGL

    • Mass

    • 1013.15

    • PI

    • 3.56

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 4

    • Net Charge

    • -2

    • Boman Index

    • 1.63

    • Hydrophobicity

    • 0.94

    • Aliphatic Index

    • 88

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 13.89

    • Polar Residues

    • 4

DRAMP01009

Comments Information

    • Function

    • Has antifungal activity against M.arachidicola with an IC50 of 1.3 µM. Has antibacterial activity against the Gram-negative bacteria P. fluorescens. Has antiproliferative activity towards L1210 leukemia cells with an IC50 of 8.33 µM.

Literature Information

  • ·Literature 1

    • Title

    • Isolation of alliumin, a novel protein with antimicrobial and antiproliferative activities from multiple-cloved garlic bulbs.

    • Reference

    • Peptides. 2005 Feb;26(2):177-183.

    • Author

    • Xia L, Ng TB.