General Information

    • DRAMP ID

    • DRAMP01090

    • Peptide Name

    • Alyteserin-2Ma (toads, amphibians, animals)

    • Source

    • Alytes maurus (Midwife toad)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FIGKLISAASGLLSHL

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=38.4 µM) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=9.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • α-Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01090 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C76H127N19O20

    • Absent Amino Acids

    • CDEMNPQRTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1626.96

    • PI

    • 8.76

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 17.59

    • Hydrophobicity

    • 1.269

    • Aliphatic Index

    • 158.75

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01090

Comments Information

    • Function

    • Has antibacterial activity against the Gram-negative bacteria E. coli and Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 150 microM.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions.

    • Reference

    • Toxicon. 2012 Nov;60(6):967-981.

    • Author

    • König E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C.