General Information
-
DRAMP ID
- DRAMP01105
-
Peptide Name
- Maximin-S4 (chain of Maximins-S type B/C; toads, amphibians, animals)
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Source
- Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
-
Family
- Belongs to the bombinin family
-
Gene
- Not found
-
Sequence
- RSNKGFNFMVDMIQALSK
-
Sequence Length
- 18
-
UniProt Entry
- Q5GC92
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- [Ref.15649437]Mycoplasma humenis (MIC=46 µM), Ureaplasma urealyticum (MIC=46 µM).
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Hemolytic Activity
-
- [Ref:15649437] Maximin S1 and S4 had no hemolytic activity.
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01105.
Physicochemical Information
-
Formula
- C91H148N26O26S2
Absent Amino Acids
- CEHPTWY
Common Amino Acids
- FKMNS
Mass
- 2086.45
PI
- 9.99
Basic Residues
- 3
Acidic Residues
- 1
Hydrophobic Residues
- 6
Net Charge
- +2
-
Boman Index
- -33.07
Hydrophobicity
- -0.256
Aliphatic Index
- 65
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP01105
Comments Information
Function
- Maximin-S3 has an activity against mycoplasma but has no activity against common Gram-positive and Gram-negative bacteria nor fungi. Has no hemolytic activity. Tissue specificity
Literature Information
- ·Literature 1
-
Title
- Maximins S, a novel group of antimicrobial peptides from toad Bombina maxima.
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Pubmed ID
- 15649437
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Reference
- Biochem Biophys Res Commun. 2005 Feb 18;327(3):945-951.
-
Author
- Wang T, Zhang J, Shen JH, Jin Y, Lee WH, Zhang Y.