General Information

    • DRAMP ID

    • DRAMP01161

    • Peptide Name

    • Uperin-7.1 (Frogs, amphibians, animals)

    • Source

    • Litoria ewingi (Brown tree frog) (Ewing's tree frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GWFDVVKHIASAV

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antiviral

    • Target Organism

      • Gram-positive bacteria: Streptococcus uberis, Lactococcus lactis.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01161 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01161.

Physicochemical Information

    • Formula

    • C68H101N17O17

    • Absent Amino Acids

    • CELMNPQRTY

    • Common Amino Acids

    • V

    • Mass

    • 1428.65

    • PI

    • 6.74

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +1

    • Boman Index

    • 4.58

    • Hydrophobicity

    • 0.831

    • Aliphatic Index

    • 112.31

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 458.33

    • Polar Residues

    • 2

DRAMP01161

Comments Information

    • Function

    • Uperin 7.1 shows antibacterial activity against L. lactis. Uperin 7.1.1 is inactive.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • An unusual combination of peptides from the skin glands of Ewing's tree frog, Litoria ewingi. Sequence determination and antimicrobial activity.

    • Reference

    • Aust. J. Chem. 1997; 50:889-894.

    • Author

    • Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.