General Information
-
DRAMP ID
- DRAMP01173
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Peptide Name
- Ocellatin-3 (Frogs, amphibians, animals)
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Source
- Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum)
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Family
- Not found
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Gene
- Not found
-
Sequence
- GVLDILKNAAKNILAHAAEQI
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Sequence Length
- 21
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UniProt Entry
- P83867
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- [Swiss_Prot Entry P83867]Gram-negative bacterium: Escherichia coli
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Hemolytic Activity
-
- [Ref:15648972]Show hemolytic activity against human red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01173.
Physicochemical Information
-
Formula
- C98H168N28O29
Absent Amino Acids
- CFMPRSTWY
Common Amino Acids
- A
Mass
- 2202.58
PI
- 6.75
Basic Residues
- 3
Acidic Residues
- 2
Hydrophobic Residues
- 12
Net Charge
- +1
-
Boman Index
- -6.56
Hydrophobicity
- 0.438
Aliphatic Index
- 149.05
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP01173
Comments Information
Function
- Has hemolytic activity against human erythrocytes and antibacterial activity against the Gram-negative bacterium E. coli.
Tissue specificity
- Expressed by the skin dorsal glands.
PTM
- C-terminal amidation.
Literature Information
- ·Literature 1
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Title
- Ocellatins: new antimicrobial peptides from the skin secretion of the South American frog Leptodactylus ocellatus (Anura: Leptodactylidae).
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Pubmed ID
- 15648972
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Reference
- Protein J. 2004 Nov;23(8):501-508.
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Author
- Nascimento AC, Zanotta LC, Kyaw CM, Schwartz EN, Schwartz CA, Sebben A, Sousa MV, Fontes W, Castro MS.